Pharmacokinetic Interactions of Nevirapine and Methadone and Guidelines for Use of Nevirapine to Treat Injection Drug Users

Administration of nevirapine to HIV-infected injection drug users who also receive methadone results in a significant reduction in methadone exposure after 7-10 days of therapy. Many patients require an increase in methadone dose to counteract this effect.

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Bibliographic Details
Published in:Clinical infectious diseases 2001-11, Vol.33 (9), p.1595-1597
Main Authors: Clarke, Susan M., Mulcahy, Fiona M., Tjia, John, Reynolds, Helen E., Gibbons, Sara E., Barry, Michael G., Back, David J.
Format: Article
Language:English
Subjects:
Adult
Analgesics, Opioid - administration & dosage
Analgesics, Opioid - pharmacokinetics
Anti-HIV Agents - administration & dosage
Anti-HIV Agents - pharmacokinetics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretrovirals
Antiviral agents
Antivirals
Biological and medical sciences
Cytochromes
Dosage
Drug Antagonism
Drug interactions
Enzymes
Female
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - virology
HIV-1 - drug effects
HIV/AIDS
Humans
Injections
Male
Medical sciences
Methadone
Methadone - administration & dosage
Methadone - pharmacokinetics
Middle Aged
Narcotic Antagonists - administration & dosage
Narcotic Antagonists - pharmacokinetics
Nevirapine - administration & dosage
Nevirapine - pharmacokinetics
Pharmacokinetics
Pharmacology. Drug treatments
Practice Guidelines as Topic
Reverse Transcriptase Inhibitors - administration & dosage
Reverse Transcriptase Inhibitors - pharmacokinetics
Substance Abuse, Intravenous - complications
Substance Abuse, Intravenous - drug therapy
Withdrawal symptoms
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Description
Summary:Administration of nevirapine to HIV-infected injection drug users who also receive methadone results in a significant reduction in methadone exposure after 7-10 days of therapy. Many patients require an increase in methadone dose to counteract this effect.
ISSN:1058-4838
1537-6591
DOI:10.1086/322519