Mutagenic effects of carbosulfan, a carbamate pesticide

The genotoxic effects of carbosulfan were evaluated using chromosome aberration (CA), bone marrow micronucleus (MN) and sperm abnormality assays in mice. All the three acute doses (1.25, 2.5 and 5mg/kg) of carbosulfan induced significant dose-dependent increase in the frequency of CA (P4.6-fold incr...

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Bibliographic Details
Published in:Mutation research. Genetic toxicology and environmental mutagenesis 2002-08, Vol.519 (1-2), p.75-82
Main Authors: Giri, Sarbani, Giri, Anirudha, Sharma, Gouri Dutt, Prasad, Surya Bali
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carbamate pesticide
Carbosulfan
Chromosome aberration
Medical sciences
Micronucleus
Pesticides, fertilizers and other agrochemicals toxicology
Sperm abnormality
Toxicology
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Summary:The genotoxic effects of carbosulfan were evaluated using chromosome aberration (CA), bone marrow micronucleus (MN) and sperm abnormality assays in mice. All the three acute doses (1.25, 2.5 and 5mg/kg) of carbosulfan induced significant dose-dependent increase in the frequency of CA (P4.6-fold increase in the frequency of sperms with abnormal head morphology following intraperitoneal exposure as compared to the untreated controls. The present findings suggest that carbosulfan is a potent genotoxic agent and may be regarded as a potential germ cell mutagen also.
ISSN:1383-5718
1879-3592
DOI:10.1016/S1383-5718(02)00114-6