Synthesis of novel substituted pyrimidine derivatives bearing a sulfamide group and their in vitro cancer growth inhibition activity

[Display omitted] The synthesis of two series of novel substituted pyrimidine derivatives bearing a sulfamide group have been described and their in vitro cancer growth inhibition activities have been evaluated against three human tumour cell lines (HT-29, M21, and MCF7). In general, growth inhibiti...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2017-01, Vol.27 (2), p.299-302
Main Authors: Lefebvre, Carole-Anne, Forcellini, Elsa, Boutin, Sophie, Côté, Marie-France, C.-Gaudreault, René, Mathieu, Patrick, Lagüe, Patrick, Paquin, Jean-François
Format: Article
Language:English
Subjects:
Anticancer activities
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cell Line, Tumor
Cell Proliferation - drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Growth inhibition
Humans
Molecular Structure
Pyrimidine
Pyrimidines - chemical synthesis
Pyrimidines - chemistry
Pyrimidines - pharmacology
Structure-Activity Relationship
Structure-activity relationships (SARs)
Sulfamide
Sulfonamides - chemistry
Sulfonamides - pharmacology
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Summary:[Display omitted] The synthesis of two series of novel substituted pyrimidine derivatives bearing a sulfamide group have been described and their in vitro cancer growth inhibition activities have been evaluated against three human tumour cell lines (HT-29, M21, and MCF7). In general, growth inhibition activity has been enhanced by the introduction of a bulky substituent on the aromatic ring with the best compound having GI50
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2016.11.052