Natural nitric oxide (NO) inhibitors from Aristolochia mollissima

Six new sesquiterpenoids, aristomollins A–F ( 1–6 ), and 24 known analogues ( 7–30 ) were isolated from the leaves and stems of Aristolochia mollissima . Their structures were elucidated by spectroscopic analysis, and the absolute configurations of compounds 2–5 were determined by the chemical corre...

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Bibliographic Details
Published in:RSC advances 2014-01, Vol.4 (98), p.55036-55043
Main Authors: Dong, Zhen, Gu, Qiong, Cheng, Bao, Cheng, Zhong-Bin, Tang, Gui-Hua, Sun, Zhang-Hua, Zhang, Jun-Sheng, Bao, Jing-Mei, Yin, Sheng
Format: Article
Language:English
Subjects:
Active control
Correlation analysis
Inhibition
Leaves
Mathematical analysis
Nitric oxide
Quantum chemistry
Stems
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Summary:Six new sesquiterpenoids, aristomollins A–F ( 1–6 ), and 24 known analogues ( 7–30 ) were isolated from the leaves and stems of Aristolochia mollissima . Their structures were elucidated by spectroscopic analysis, and the absolute configurations of compounds 2–5 were determined by the chemical correlations and quantum chemical ECD calculations. Compound 1 represented an unprecedented 5,6- seco -4,5-cyclohumulane skeleton. All the compounds were examined for their inhibitory effects on the nitric oxide (NO) production induced by lipopolysaccharide (LPS) in BV-2 microglial cells, and compounds 4 , 9 , 28 , and 30 exhibited pronounced inhibition of NO production with IC 50 values in the range of 5.7–9.9 μM, being more active than the positive control, quercetin (IC 50 = 15.7 μM).
ISSN:2046-2069
2046-2069
DOI:10.1039/C4RA09612F