Antimicrobial activities of phosphonium containing polynorbornenes

In this study, amphiphilic polyoxanorbornene with different alkyl and aromatic phosphonium side chains was synthesized. The biological activities of these polymers were determined by the minimal inhibitory concentration (MIC) against E. coli, S. aureus, M. tuberculosis and the yeast C. albicans, and...

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Bibliographic Details
Published in:RSC advances 2016-01, Vol.6 (89), p.86151-86157
Main Authors: Sueer, NCeren, Demir, Ceren, Uenuebol, Nihan A, Yalcin, Oezlem, Kocagoz, Tanil, Eren, Tarik
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Bacteria
Biological activity
Carbon
Escherichia coli
Molecular weight
Mycobacterium
Polymers
Staphylococcus aureus
Tuberculosis
Zeta potential
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Summary:In this study, amphiphilic polyoxanorbornene with different alkyl and aromatic phosphonium side chains was synthesized. The biological activities of these polymers were determined by the minimal inhibitory concentration (MIC) against E. coli, S. aureus, M. tuberculosis and the yeast C. albicans, and cytotoxicity studies on red blood cells were performed. A series of polymers with different alkyl and aromatic substituents (methyl, ethyl, tripropyl, tert-butyl, phenyl, and tris 4-methoxyphenyl) and two types different molecular weight, 3000 g mol-1 and 10 000 g mol-1, were prepared. It was observed that the biological activity of the polymers with aromatic group substituents had an MIC of 16, 8, 64 and 128 mu g mL-1 against E. coli, S. aureus, M. tuberculosis and C. albicans, respectively, while those with non-aromatic carbons had a higher MIC compared to those with aromatic carbons. The aromaticity of the repeat unit had impressive effects on hemolytic activities as well. Zeta potential measurements of E. coli incubated with active and inactive polymer concentration revealed a relationship between the MIC and membrane surface charge density. Polymers bearing aromatic groups killed the bacteria with widespread damage after the polymers, holding the threshold concentration, were added to the bacteria.
ISSN:2046-2069
2046-2069
DOI:10.1039/c6ra15545f