Synthesis and antiproliferative activity of N-glycosyl-3,3-diaryloxindoles

N-Glycosylated 3,3-diaryloxindoles were prepared by Lewis acid catalyzed reaction of acetylated N-glycosylisatins with various benzene derivatives and subsequent deprotection. Some of the products showed antiproliferative activity against malignant cutaneous melanoma cells HT-144 (ATCC HTB-63) and l...

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Bibliographic Details
Published in:RSC advances 2014-01, Vol.4 (44), p.22828-22839
Main Authors: Kleeblatt, Dennis, Cordes, Christoph A., Lebrenz, Philipp, Hein, Martin, Feist, Holger, Matin, Abdul, Raza, Rabia, Iqbal, Jamshed, Munshi, Omar, Rahman, Qamar, Villinger, Alexander, Langer, Peter
Format: Article
Language:English
Subjects:
Antiproliferatives
Benzene
Biotechnology
Cancer
Chemical reactions
Derivatives
Lewis acid
Synthesis
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Summary:N-Glycosylated 3,3-diaryloxindoles were prepared by Lewis acid catalyzed reaction of acetylated N-glycosylisatins with various benzene derivatives and subsequent deprotection. Some of the products showed antiproliferative activity against malignant cutaneous melanoma cells HT-144 (ATCC HTB-63) and lung carcinoma (H157) cell lines (ATCC CRL-5802).
ISSN:2046-2069
2046-2069
DOI:10.1039/c4ra02627f