Synthesis and in vitro phantom NMR and MRI studies of fully organic free radicals, TEEPO-glucose and TEMPO-glucose, potential contrast agents for MRI

Two organic radical contrast agents, TEMPO-Glc and TEEPO-Glc, were synthesized and their stabilities and contrast enhancing properties were tested with in vitro NMR and MRI experiments. Owing to the glucose moieties in the prepared compounds, this study presents potential candidates for a tumor targ...

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Bibliographic Details
Published in:RSC advances 2015-01, Vol.5 (20), p.15507-15510
Main Authors: Soikkeli, M., Sievänen, K., Peltonen, J., Kaasalainen, T., Timonen, M., Heinonen, P., Rönkkö, S., Lehto, V.-P., Kavakka, J. S., Heikkinen, S.
Format: Article
Language:English
Subjects:
Contrast agents
Free radicals
Glucose
Nuclear magnetic resonance
Radicals
Stability
Synthesis
Tumors
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Summary:Two organic radical contrast agents, TEMPO-Glc and TEEPO-Glc, were synthesized and their stabilities and contrast enhancing properties were tested with in vitro NMR and MRI experiments. Owing to the glucose moieties in the prepared compounds, this study presents potential candidates for a tumor targeting fully organic contrast agents for MRI.
ISSN:2046-2069
2046-2069
DOI:10.1039/C4RA11455H