Highly efficient and low toxic skin penetrants composed of amino acid ionic liquids

Herein, we introduce an amino acid ester (AAE) as a potent biocompatible counter ion to formulate ionic liquefied active pharmaceutical ingredients. By equimolar pairing of a non-steroidal anti-inflammatory drug (NSAID) as the anion and the AAE as the cation, the liquid formulation was feasibly obta...

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Bibliographic Details
Published in:RSC advances 2016-01, Vol.6 (90), p.87753-87755
Main Authors: Furukawa, Shin-ya, Hattori, Gaku, Sakai, Shinji, Kamiya, Noriho
Format: Article
Language:English
Subjects:
Amino acids
Biocompatibility
Cations
Drug delivery systems
Drugs
Formulations
Ionic liquids
Permeation
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Summary:Herein, we introduce an amino acid ester (AAE) as a potent biocompatible counter ion to formulate ionic liquefied active pharmaceutical ingredients. By equimolar pairing of a non-steroidal anti-inflammatory drug (NSAID) as the anion and the AAE as the cation, the liquid formulation was feasibly obtained. In vitro drug permeation results using pig skin revealed a significant enhancement of the transdermal delivery of the ionic liquefied NSAIDs. The AAE showed much lower cytotoxicity to mouse fibroblast L929 cells when compared with that of conventional counter cations, indicating the significant potential of the AAE in the development of new ionic liquid drug formulations.
ISSN:2046-2069
2046-2069
DOI:10.1039/C6RA16926K