Relationship between paired cord blood and milk POPs levels as a tool for assessing perinatal exposure, a pilot study

The long-term health threats posed to humans exposed to pollutants acting as endocrine disruptors (EDs) is yet to be quantified. There is insufficient knowledge about the sources and magnitude of exposure to selected polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) during...

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Published in:Human and ecological risk assessment 2016-10, Vol.22 (7), p.1456-1468
Main Authors: Hernik, Agnieszka, Struciński, Paweł, Buckley, Brian T., Góralczyk, Katarzyna, Czaja, Katarzyna, Korcz, Wojciech, Matuszak, Małgorzata, Łyczewska, Monika, Minorczyk, Maria, Liszewska, Monika, Ludwicki, Jan K.
Format: Article
Language:English
Subjects:
Blood
Breast
breast milk
Breastfeeding & lactation
cord blood
Endocrine disruptors
Ethers
Exposure
Fire resistant materials
Milk
organohalogen contaminants
PCB
Pesticides
Poland
Pollutants
Polychlorinated biphenyls
Rope
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Summary:The long-term health threats posed to humans exposed to pollutants acting as endocrine disruptors (EDs) is yet to be quantified. There is insufficient knowledge about the sources and magnitude of exposure to selected polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) during the most sensitive period of fetal development, suggesting the need for a study. Organochlorine pesticides, classified as being persistent organic pollutants (POPs) and potential EDs, were also included in this analysis. Xenobiotics were measured in paired fetal cord blood and maternal breast milk samples. There were no significant differences in the concentrations of PCB-101, PBDE-47, and PBDE-99 between maternal milk and cord blood according to the Wilcoxon test, and the Spearman tests demonstrated significant correlations in β-HCH, γ-HCH, p,p'-DDE, and PCB-118 between maternal milk and cord blood from the same subjects. All others tested (HCB, β-HCH, γ-HCH, p,p'-DDE, p,p'-DDD, p,p'-DDT, PCB-101, PCB-138, PCB-153, PCB-170, PCB-180, PBDE-153) demonstrated significant differences in the same subject women with concentrations significantly higher in maternal milk than in cord blood. The presence of these compounds found in cord blood and maternal milk indicates that both are a source of perinatal exposure to these pollutants. This study opens up the opportunity for new research in estimating a prenatal exposure based on breast milk concentrations of organohalogen compounds.
ISSN:1080-7039
1549-7860
DOI:10.1080/10807039.2016.1185688