Catalyst-free synthesis of (7E)-7-benzylidene-3,3a,4,5,6,7-hexahydro-2,3-diphenyl-2H-indazole derivatives in PEG-400 as a green and reusable solvent

The reaction of 2,6-bisbenzylidenecyclohexanones and phenylhydrazine in polyethylene glycol (PEG)-400 as a green and reusable solvent under catalyst-free conditions gave hexahydroindazoles as the major product and, in some cases, tetrahydroindazoles were also produced as a minor product. The product...

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Bibliographic Details
Published in:Journal of chemical research 2016-09, Vol.40 (9), p.535-539
Main Authors: Amoozadeh, Ali, Tabrizian, Elham, Salehi, Mehdi, Kubicki, Maciej, Rahmani, Salman, Shamsi, Taiebeh, Bitaraf, Mehrnoosh
Format: Article
Language:English
Subjects:
Catalysts
Derivatives
Fourier transforms
Infrared spectroscopy
NMR spectroscopy
Polyethylene glycol
Solvents
X-rays
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Summary:The reaction of 2,6-bisbenzylidenecyclohexanones and phenylhydrazine in polyethylene glycol (PEG)-400 as a green and reusable solvent under catalyst-free conditions gave hexahydroindazoles as the major product and, in some cases, tetrahydroindazoles were also produced as a minor product. The products were easily separated by simple recrystallisation. The structures of the indazoles were confirmed using FTIR and NMR spectroscopy. Two X-ray structures are reported.
ISSN:1747-5198
2047-6507
DOI:10.3184/174751916X14709222930154