White spot lesion remineralization by sugar-free chewing gum containing bio-available calcium and fluoride: A double-blind randomized controlled trial

Abstract Objectives To assess the effect of chewing gum containing phosphoryl oligosaccharides of calcium (POs-Ca) and fluoride on white spot lesion (WSL) remineralization in comparison with POs-Ca or placebo (control) chewing gums, in double- blind, randomized, controlled trial. Methods Thirty-seve...

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Bibliographic Details
Published in:Journal of dentistry 2016-11, Vol.54, p.86-91
Main Authors: Sugiura, Miho, Kitasako, Yuichi, Sadr, Alireza, Shimada, Yasushi, Sumi, Yasunori, Tagami, Junji
Format: Article
Language:English
Subjects:
Bioavailability
Calcium
Calcium fluoride
Chewing
Chewing Gum
Chewing gums
Clinical trials
Dental Caries
Dentistry
Double-blind
Double-Blind Method
Enamel
Fluorides
Humans
Lesions
Optical properties
Randomized controlled trial
Rank tests
Remineralization
Spots
Sugars
Teeth
Tooth Remineralization
White spot
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Summary:Abstract Objectives To assess the effect of chewing gum containing phosphoryl oligosaccharides of calcium (POs-Ca) and fluoride on white spot lesion (WSL) remineralization in comparison with POs-Ca or placebo (control) chewing gums, in double- blind, randomized, controlled trial. Methods Thirty-seven healthy subjects, who had at least one WSL, with an ICDAS score of 2 or 1, were recruited for this study. The subjects were randomly divided into three groups (control, POs-Ca, POs-Ca + F) and chewed two slabs of each gum three times every day for 3 months. WSLs were assessed using ICDAS criteria and optical boundary depth (BD) by optical coherence tomography (OCT) system at a monthly recall. Data were analyzed by Wilcoxon rank-sum test and Wilcoxon signed rank test with Bonferroni corrections at 0.05 significance level. Results Visual score changes from ICDAS score 2 to score 1 over the course of the study were observed; control (30%), POs-Ca (48%) and POs-Ca + F (45%). Unlike the control gum, chewing POs-Ca and POs-Ca + F gums resulted in significant changes in the mean value of BD over the 3 months course of the study (p < 0.05). There was a significant difference in mean value of BD after first month between POs-Ca + F and control groups (p < 0.05). Conclusions This study highlighted the importance of calcium and fluoride ion bioavailability in the reinforcement of demineralized enamel lesions by chewing gums. Furthermore, adding fluoride to POs-Ca might speed up the remineralization progress on natural WSL.
ISSN:0300-5712
1879-176X
DOI:10.1016/j.jdent.2016.09.003