Superparamagnetic anisotropic nano-assemblies with longer blood circulation in vivo: a highly efficient drug delivery carrier for leukemia therapy

Leukemia, unlike solid tumors, has no definite shape and spreads throughout the whole circulatory system, therefore the therapy of leukemia requires medication to stay longer in the circulatory system. Anisotropic nanoparticles, showing longer blood circulating life than that of isotropic nanopartic...

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Bibliographic Details
Published in:Nanoscale 2016-10, Vol.8 (39), p.17085-17089
Main Authors: Xiong, Fei, Tian, Jilai, Hu, Ke, Zheng, Xiawen, Sun, Jianfei, Yan, Caiyun, Yao, Juan, Song, Lina, Zhang, Yu, Gu, Ning
Format: Article
Language:English
Subjects:
Animals
Anisotropy
Blood circulation
Circulatory system
Drug Carriers
Drugs
Ferric Compounds
Group dynamics
Humans
K562 Cells
Leukemia - drug therapy
Leukemias
Magnetite Nanoparticles
Mice
Nanostructure
Therapy
Vincristine - administration & dosage
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Summary:Leukemia, unlike solid tumors, has no definite shape and spreads throughout the whole circulatory system, therefore the therapy of leukemia requires medication to stay longer in the circulatory system. Anisotropic nanoparticles, showing longer blood circulating life than that of isotropic nanoparticles reported in previous research, meet the demands of leukemia therapy. Based on this strategy, superparamagnetic anisotropic nano-assemblies (SANs) were fabricated and loaded with vincristine (VCR) to form VCR-SANs. When compared to the same dose of VCR-loaded isotropic nano-assemblies (SINs), the decrease in the leukocytes count and the positive expression ratio of CD13 in the VCR-SANs group were 19.38% and 16.4%, respectively, which indicated the improved anti-leukemia activity of the VCR-SANs. From the results of the pharmacokinetics study, the VCR-SANs remarkably held the amount of drug removed from the whole body per unit time half of the isotropic group and the concentration of drug in blood plasma against time was 2.1 times the isotropic group, demonstrating the rapid and sustained release behavior and longer blood circulation when combined with the results of in vivo tissue distribution studies. In summary, anisotropic nano-assemblies were found to be more promising than isotropic nano-assemblies via our in vivo and in vitro examinations.
ISSN:2040-3364
2040-3372
DOI:10.1039/c6nr05781k