FRET optofluidic microlasers enhance biological sensing

Biological molecules-proteins or nucleic acids--are commonly studied by tagging them with light-emitting fluorescent markers. When two different markers with suitable spectral profiles are linked to a single molecule of interest, fluorescence resonance energy transfer (FRET) between these markers ca...

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Bibliographic Details
Published in:Laser focus world 2016-06, Vol.52 (6), p.54-54
Main Authors: Karadag, Yasin, Jonás, Alexandr, Kiraz, Alper
Format: Magazinearticle
Language:English
Subjects:
Energy transfer
Fluorescence
Fretting
Lasers
Markers
Microlasers
Molecules
Nucleic acids
Sensors
Spectra
Stimuli
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Summary:Biological molecules-proteins or nucleic acids--are commonly studied by tagging them with light-emitting fluorescent markers. When two different markers with suitable spectral profiles are linked to a single molecule of interest, fluorescence resonance energy transfer (FRET) between these markers can serve as a precise ruler for measuring distances within or between the molecules with atomic-scale resolution. Changes of intramolecular and intermolecular distances then directly report on the molecular activity triggered by controlled external stimuli. Here, Karadag et al discuss the FRET-based biosensing.
ISSN:1043-8092