Mild and Direct Multiple Deuterium-Labeling of Saturated Fatty Acids

We have established a mild and direct platinum on carbon (Pt/C)‐catalyzed multi‐deuterium labeling of various saturated fatty acids including bioactive compounds with high deuterium efficiencies in a mixed solvent of isopropyl alcohol and deuterium oxide (i‐PrOH)/D2O under neutral conditions at 120 ...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2016-10, Vol.358 (20), p.3277-3282
Main Authors: Yamada, Tsuyoshi, Park, Kwihwan, Yasukawa, Naoki, Morita, Kosuke, Monguchi, Yasunari, Sawama, Yoshinari, Sajiki, Hironao
Format: Article
Language:English
Subjects:
Biocompatibility
Carbon
Deuterium
Efficiency
Fatty acids
Heavy water
isopropyl alcohol
Platinum
platinum on carbon
Solvents
valproic acid
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Summary:We have established a mild and direct platinum on carbon (Pt/C)‐catalyzed multi‐deuterium labeling of various saturated fatty acids including bioactive compounds with high deuterium efficiencies in a mixed solvent of isopropyl alcohol and deuterium oxide (i‐PrOH)/D2O under neutral conditions at 120 °C without the external addition of deuterium or hydrogen gas.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201600363