Concurrent estimation of metabolite concentrations along with parent drug quantification in post-mortem blood

Highlights • Method to estimate metabolite concentrations without reference standard is reported • UHPLC with photodiode array and corona charged aerosol detection was used • Metabolite calibration was performed concurrently based on parent drugs • Non-MS detection showed similar response to parent...

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Bibliographic Details
Published in:Forensic science international 2016-10, Vol.267, p.110-114
Main Authors: Viinamaeki, Jenni, Ojanperae, Ilkka
Format: Article
Language:English
Subjects:
Aerosols - analysis
Aqueous solutions
Atoms & subatomic particles
Blood
Calibration
Chromatography
Chromatography, High Pressure Liquid - methods
Corona charged aerosol detection
Detectors
Drug metabolite quantification
Drugs
Efficiency
Forensic sciences
Humans
Ions
Laboratories
Metabolites
Nitrogen
Parents
Particle size
Pathology
Pharmaceutical industry
Pharmaceutical Preparations - blood
Photodiode array detection
Post-mortem blood
Postmortem Changes
Ratios
Sensors
Toxicology
Ultra-high performance liquid chromatography
Universal detection
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Summary:Highlights • Method to estimate metabolite concentrations without reference standard is reported • UHPLC with photodiode array and corona charged aerosol detection was used • Metabolite calibration was performed concurrently based on parent drugs • Non-MS detection showed similar response to parent drugs and N -demethyl metabolites • Metabolite concentrations were retrieved from previously generated analytical data
ISSN:0379-0738
1872-6283
DOI:10.1016/j.forsciint.2016.08.031