Concurrent estimation of metabolite concentrations along with parent drug quantification in post-mortem blood

Highlights • Method to estimate metabolite concentrations without reference standard is reported • UHPLC with photodiode array and corona charged aerosol detection was used • Metabolite calibration was performed concurrently based on parent drugs • Non-MS detection showed similar response to parent...

Full description

Saved in:
Bibliographic Details
Published in:Forensic science international 2016-10, Vol.267, p.110-114
Main Authors: Viinamaeki, Jenni, Ojanperae, Ilkka
Format: Article
Language:English
Subjects:
Aerosols - analysis
Aqueous solutions
Atoms & subatomic particles
Blood
Calibration
Chromatography
Chromatography, High Pressure Liquid - methods
Corona charged aerosol detection
Detectors
Drug metabolite quantification
Drugs
Efficiency
Forensic sciences
Humans
Ions
Laboratories
Metabolites
Nitrogen
Parents
Particle size
Pathology
Pharmaceutical industry
Pharmaceutical Preparations - blood
Photodiode array detection
Post-mortem blood
Postmortem Changes
Ratios
Sensors
Toxicology
Ultra-high performance liquid chromatography
Universal detection
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c546t-7d11bb598660174707d78ec53a442725015853ea9a6fa5141cca0e88234575823
cites cdi_FETCH-LOGICAL-c546t-7d11bb598660174707d78ec53a442725015853ea9a6fa5141cca0e88234575823
container_end_page 114
container_issue
container_start_page 110
container_title Forensic science international
container_volume 267
creator Viinamaeki, Jenni
Ojanperae, Ilkka
description Highlights • Method to estimate metabolite concentrations without reference standard is reported • UHPLC with photodiode array and corona charged aerosol detection was used • Metabolite calibration was performed concurrently based on parent drugs • Non-MS detection showed similar response to parent drugs and N -demethyl metabolites • Metabolite concentrations were retrieved from previously generated analytical data
doi_str_mv 10.1016/j.forsciint.2016.08.031
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1845814026</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0379073816303619</els_id><sourcerecordid>4213685501</sourcerecordid><originalsourceid>FETCH-LOGICAL-c546t-7d11bb598660174707d78ec53a442725015853ea9a6fa5141cca0e88234575823</originalsourceid><addsrcrecordid>eNqNkktv3CAURlHVqJmm_QstUjfd2OEN3lSKRn1JkbpIukYY45SpDRPAqfLvizNpKmU1KyQ49-NeDgC8x6jFCIvzXTvGlK33obSkbrRItYjiF2CDlSSNIIq-BBtEZdcgSdUpeJ3zDiHEORGvwCmRvJOE0w2YtzHYJSUXCnS5-NkUHwOMI5xdMX2cfHHQVqYC6eEsQzPFcAP_-PIL7s1D5ZCWG3i7mFD86O0hwge4j7k0c0zFzbCfYhzegJPRTNm9fVzPwM8vn6-335rLH1-_by8uG8uZKI0cMO573ikhEJZMIjlI5SynhjFS-0aYK06d6YwYDccMW2uQU4pQxiWvyxn4eMjdp3i71Ln07LN102SCi0vWWDGuMENEHIFSXp-RMHQESqTqWO27oh-eobu4pFBnXilFRCfUSskDZVPMOblR71M1kO41Rnr1rHf6ybNePWukdPVcK9895i_97Ianun9iK3BxAFx95jvvkq4prmocfHK26CH6Iy759CzDTj5Uv9Nvd-_y_4l0Jhrpq_W7rb8NC4qowB39C8l-0g4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1828269688</pqid></control><display><type>article</type><title>Concurrent estimation of metabolite concentrations along with parent drug quantification in post-mortem blood</title><source>Elsevier</source><creator>Viinamaeki, Jenni ; Ojanperae, Ilkka</creator><creatorcontrib>Viinamaeki, Jenni ; Ojanperae, Ilkka</creatorcontrib><description>Highlights • Method to estimate metabolite concentrations without reference standard is reported • UHPLC with photodiode array and corona charged aerosol detection was used • Metabolite calibration was performed concurrently based on parent drugs • Non-MS detection showed similar response to parent drugs and N -demethyl metabolites • Metabolite concentrations were retrieved from previously generated analytical data</description><identifier>ISSN: 0379-0738</identifier><identifier>EISSN: 1872-6283</identifier><identifier>DOI: 10.1016/j.forsciint.2016.08.031</identifier><identifier>PMID: 27597253</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Aerosols - analysis ; Aqueous solutions ; Atoms &amp; subatomic particles ; Blood ; Calibration ; Chromatography ; Chromatography, High Pressure Liquid - methods ; Corona charged aerosol detection ; Detectors ; Drug metabolite quantification ; Drugs ; Efficiency ; Forensic sciences ; Humans ; Ions ; Laboratories ; Metabolites ; Nitrogen ; Parents ; Particle size ; Pathology ; Pharmaceutical industry ; Pharmaceutical Preparations - blood ; Photodiode array detection ; Post-mortem blood ; Postmortem Changes ; Ratios ; Sensors ; Toxicology ; Ultra-high performance liquid chromatography ; Universal detection</subject><ispartof>Forensic science international, 2016-10, Vol.267, p.110-114</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2016 Elsevier Ireland Ltd</rights><rights>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Oct 1, 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c546t-7d11bb598660174707d78ec53a442725015853ea9a6fa5141cca0e88234575823</citedby><cites>FETCH-LOGICAL-c546t-7d11bb598660174707d78ec53a442725015853ea9a6fa5141cca0e88234575823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27597253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Viinamaeki, Jenni</creatorcontrib><creatorcontrib>Ojanperae, Ilkka</creatorcontrib><title>Concurrent estimation of metabolite concentrations along with parent drug quantification in post-mortem blood</title><title>Forensic science international</title><addtitle>Forensic Sci Int</addtitle><description>Highlights • Method to estimate metabolite concentrations without reference standard is reported • UHPLC with photodiode array and corona charged aerosol detection was used • Metabolite calibration was performed concurrently based on parent drugs • Non-MS detection showed similar response to parent drugs and N -demethyl metabolites • Metabolite concentrations were retrieved from previously generated analytical data</description><subject>Aerosols - analysis</subject><subject>Aqueous solutions</subject><subject>Atoms &amp; subatomic particles</subject><subject>Blood</subject><subject>Calibration</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Corona charged aerosol detection</subject><subject>Detectors</subject><subject>Drug metabolite quantification</subject><subject>Drugs</subject><subject>Efficiency</subject><subject>Forensic sciences</subject><subject>Humans</subject><subject>Ions</subject><subject>Laboratories</subject><subject>Metabolites</subject><subject>Nitrogen</subject><subject>Parents</subject><subject>Particle size</subject><subject>Pathology</subject><subject>Pharmaceutical industry</subject><subject>Pharmaceutical Preparations - blood</subject><subject>Photodiode array detection</subject><subject>Post-mortem blood</subject><subject>Postmortem Changes</subject><subject>Ratios</subject><subject>Sensors</subject><subject>Toxicology</subject><subject>Ultra-high performance liquid chromatography</subject><subject>Universal detection</subject><issn>0379-0738</issn><issn>1872-6283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkktv3CAURlHVqJmm_QstUjfd2OEN3lSKRn1JkbpIukYY45SpDRPAqfLvizNpKmU1KyQ49-NeDgC8x6jFCIvzXTvGlK33obSkbrRItYjiF2CDlSSNIIq-BBtEZdcgSdUpeJ3zDiHEORGvwCmRvJOE0w2YtzHYJSUXCnS5-NkUHwOMI5xdMX2cfHHQVqYC6eEsQzPFcAP_-PIL7s1D5ZCWG3i7mFD86O0hwge4j7k0c0zFzbCfYhzegJPRTNm9fVzPwM8vn6-335rLH1-_by8uG8uZKI0cMO573ikhEJZMIjlI5SynhjFS-0aYK06d6YwYDccMW2uQU4pQxiWvyxn4eMjdp3i71Ln07LN102SCi0vWWDGuMENEHIFSXp-RMHQESqTqWO27oh-eobu4pFBnXilFRCfUSskDZVPMOblR71M1kO41Rnr1rHf6ybNePWukdPVcK9895i_97Ianun9iK3BxAFx95jvvkq4prmocfHK26CH6Iy759CzDTj5Uv9Nvd-_y_4l0Jhrpq_W7rb8NC4qowB39C8l-0g4</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Viinamaeki, Jenni</creator><creator>Ojanperae, Ilkka</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>20161001</creationdate><title>Concurrent estimation of metabolite concentrations along with parent drug quantification in post-mortem blood</title><author>Viinamaeki, Jenni ; Ojanperae, Ilkka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c546t-7d11bb598660174707d78ec53a442725015853ea9a6fa5141cca0e88234575823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aerosols - analysis</topic><topic>Aqueous solutions</topic><topic>Atoms &amp; subatomic particles</topic><topic>Blood</topic><topic>Calibration</topic><topic>Chromatography</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Corona charged aerosol detection</topic><topic>Detectors</topic><topic>Drug metabolite quantification</topic><topic>Drugs</topic><topic>Efficiency</topic><topic>Forensic sciences</topic><topic>Humans</topic><topic>Ions</topic><topic>Laboratories</topic><topic>Metabolites</topic><topic>Nitrogen</topic><topic>Parents</topic><topic>Particle size</topic><topic>Pathology</topic><topic>Pharmaceutical industry</topic><topic>Pharmaceutical Preparations - blood</topic><topic>Photodiode array detection</topic><topic>Post-mortem blood</topic><topic>Postmortem Changes</topic><topic>Ratios</topic><topic>Sensors</topic><topic>Toxicology</topic><topic>Ultra-high performance liquid chromatography</topic><topic>Universal detection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Viinamaeki, Jenni</creatorcontrib><creatorcontrib>Ojanperae, Ilkka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Toxicology Abstracts</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Forensic science international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Viinamaeki, Jenni</au><au>Ojanperae, Ilkka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Concurrent estimation of metabolite concentrations along with parent drug quantification in post-mortem blood</atitle><jtitle>Forensic science international</jtitle><addtitle>Forensic Sci Int</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>267</volume><spage>110</spage><epage>114</epage><pages>110-114</pages><issn>0379-0738</issn><eissn>1872-6283</eissn><abstract>Highlights • Method to estimate metabolite concentrations without reference standard is reported • UHPLC with photodiode array and corona charged aerosol detection was used • Metabolite calibration was performed concurrently based on parent drugs • Non-MS detection showed similar response to parent drugs and N -demethyl metabolites • Metabolite concentrations were retrieved from previously generated analytical data</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>27597253</pmid><doi>10.1016/j.forsciint.2016.08.031</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0379-0738
ispartof Forensic science international, 2016-10, Vol.267, p.110-114
issn 0379-0738
1872-6283
language eng
recordid cdi_proquest_miscellaneous_1845814026
source Elsevier
subjects Aerosols - analysis
Aqueous solutions
Atoms & subatomic particles
Blood
Calibration
Chromatography
Chromatography, High Pressure Liquid - methods
Corona charged aerosol detection
Detectors
Drug metabolite quantification
Drugs
Efficiency
Forensic sciences
Humans
Ions
Laboratories
Metabolites
Nitrogen
Parents
Particle size
Pathology
Pharmaceutical industry
Pharmaceutical Preparations - blood
Photodiode array detection
Post-mortem blood
Postmortem Changes
Ratios
Sensors
Toxicology
Ultra-high performance liquid chromatography
Universal detection
title Concurrent estimation of metabolite concentrations along with parent drug quantification in post-mortem blood
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T13%3A21%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Concurrent%20estimation%20of%20metabolite%20concentrations%20along%20with%20parent%20drug%20quantification%20in%20post-mortem%20blood&rft.jtitle=Forensic%20science%20international&rft.au=Viinamaeki,%20Jenni&rft.date=2016-10-01&rft.volume=267&rft.spage=110&rft.epage=114&rft.pages=110-114&rft.issn=0379-0738&rft.eissn=1872-6283&rft_id=info:doi/10.1016/j.forsciint.2016.08.031&rft_dat=%3Cproquest_cross%3E4213685501%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c546t-7d11bb598660174707d78ec53a442725015853ea9a6fa5141cca0e88234575823%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1828269688&rft_id=info:pmid/27597253&rfr_iscdi=true