P020Molecular biomarkers for malignant pleural mesothelioma in mexico

BackgroundMalignant pleural mesothelioma (MPM) is a lethal cancer. There is an epidemic of MPM in Mexico with 500 cases per year. The diagnosis remains a challenge, so it is relevant to develop inexpensive and less invasive diagnostic tests.Objectivedetermine the sensitivity and specificity in calre...

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Published in:Occupational and environmental medicine (London, England) England), 2016-09, Vol.73 (Suppl 1), p.A126-A126
Main Authors: Aguilar-Madrid, Guadalupe, Juarez-Perez, Arturo, Aranda, Emma Calderon, Vazquez, Maria Dolores Ochoa, Torre-Bouscoulet, Luis, Jimenez-Ramirez, Carmina, Johnen, George
Format: Article
Language:English
Subjects:
Biomarkers
Cut-off
Diagnosis
Diagnostic systems
Men
Mesothelioma
Occupational
Sex
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Summary:BackgroundMalignant pleural mesothelioma (MPM) is a lethal cancer. There is an epidemic of MPM in Mexico with 500 cases per year. The diagnosis remains a challenge, so it is relevant to develop inexpensive and less invasive diagnostic tests.Objectivedetermine the sensitivity and specificity in calretinin plasma mesothelin and to improve the diagnosis of mesothelioma malignant pleuralMaterial and methodsCase-control study from three different hospitals; MPM cases were confirmed by immunohistochemistry and histopathology. Asbestos exposure was assessed using a clinical and occupational questionnaire. Biomarkers levels were measured using ELISA. Based on ROC curves and the highest sensitivity, cut-off points were established for each biomarker. A logistic regression model was built to obtain odds ratios (OR) and 95% confidence intervals for each biomarker.Results190 MPM cases and 600 controls were included. Biomarkers mean levels were statistically different between cases and controls and between sexes. Area under the curve (AUC), sensitivity and cut-off points were determined: mesothelin 0.91, 90.9% and 1.59 nmol/l; calretinin 0.85, 94% and 0.69 nmol/l. In the logistic model for both sexes, based on cut-off points, the OR were: mesothelin > 0,74 nmol/l: OR = 13.5 (5.7-33.5); calretinin > 0.23 ng/ml: OR = 10 (4.6-21.7). Models weighted by sex showed differences between men and women in calretinin levels, which showed a poor performance in women.ConclusionMesothelin and calretinin showed a good performance in men and cut-off points support the diagnostic accuracy differentiated by sex in MPM cases. Cut-off points and biomarkers levels should be analysed separately by sex.
ISSN:1351-0711
DOI:10.1136/oemed-2016-103951.345