The relationship between thyroid function and the prevalence of type 2 diabetes mellitus in euthyroid subjects

Purpose:The thyroid hormones (TH) are primarily responsible for the regulation of energy balance and metabolism, suggesting that TH levels may contribute to the development of type 2 diabetes mellitus (T2DM). However, few studies have investigated the relationship between TH and T2DM in a general po...

Full description

Saved in:
Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2017-02, Vol.102 (2), p.434-442
Main Authors: Gu, Yeqing, Li, Huihui, Bao, Xue, Zhang, Qing, Liu, Li, Meng, Ge, Wu, Hongmei, Du, Huanmin, Shi, Hongbin, Xia, Yang, Su, Qian, Fang, Liyun, Yu, Fei, Yang, Huijun, Yu, Bin, Sun, Shaomei, Wang, Xing, Zhou, Ming, Jia, Qiyu, Guo, Qi, Chang, Hong, Wang, Guolin, Huang, Guowei, Song, Kun, Niu, Kaijun
Format: Article
Language:English
Subjects:
Adult
Chemiluminescence
China - epidemiology
Cross-Sectional Studies
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - physiopathology
Energy balance
Energy metabolism
Female
Females
Health risk assessment
Hormones
Humans
Immunoassay
Male
Males
Middle Aged
Prevalence
Regression analysis
Sex Factors
Thyroid Function Tests
Thyroid gland
Thyroid Gland - physiopathology
Thyroid hormones
Thyroid Hormones - blood
Thyroid-stimulating hormone
Thyrotropin - blood
Thyroxine
Thyroxine - blood
Triiodothyronine
Triiodothyronine - blood
Young Adult
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose:The thyroid hormones (TH) are primarily responsible for the regulation of energy balance and metabolism, suggesting that TH levels may contribute to the development of type 2 diabetes mellitus (T2DM). However, few studies have investigated the relationship between TH and T2DM in a general population. The aim of this study is to evaluate whether serum TH levels within the reference range are related to T2DM.Methods:A cross-sectional study (n=15,296) was performed in Tianjin, China. Serum free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) levels were measured by chemiluminescence immunoassay, and T2DM was defined according to the American Diabetes Association criteria. Multiple logistic regression models were used to assess the gender-specific relationships between FT3, FT4, FT3/FT4 ratios and TSH quintiles and T2DM.Results:The prevalence of T2DM was 16.2% in males and 7.7% in females, respectively. In males, the multivariable-adjusted odds ratios (95% confidence interval) of T2DM for increasing quintiles of FT3, FT4 and FT3/FT4 ratios were 1.00, 0.75(0.63-0.89), 0.70(0.58-0.84), 0.63(0.52-0.76), 0.56(0.46-0.68) (P for trend
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2016-2965