Detection of novel GII.17 norovirus in Argentina, 2015

During the winter of 2014–2015 a novel GII.17 norovirus strain emerged as a cause of large gastroenteritis outbreaks in Asia; displacing the long-term predominant strain, GII.4. Although sporadically detected, the emerging GII.17 virus was described in North America and Europe. In this study, we des...

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Bibliographic Details
Published in:Infection, genetics and evolution genetics and evolution, 2017-01, Vol.47, p.121-124
Main Authors: Degiuseppe, Juan I., Gomes, Karina A., Hadad, María F., Parra, Gabriel I., Stupka, Juan A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Argentina
Caliciviridae Infections - virology
Capsid Proteins - genetics
Child
Child, Preschool
Feces - virology
Gastroenteritis
Gastroenteritis - virology
Genotype
GII.17
Humans
Infant
Middle Aged
Norovirus
Norovirus - classification
Norovirus - genetics
Phylogeny
Young Adult
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Summary:During the winter of 2014–2015 a novel GII.17 norovirus strain emerged as a cause of large gastroenteritis outbreaks in Asia; displacing the long-term predominant strain, GII.4. Although sporadically detected, the emerging GII.17 virus was described in North America and Europe. In this study, we describe the presence of this novel strain in Argentina (South America), and provide new information on the genetic diversity of GII.17 noroviruses. Ten stool samples from individuals (1–88years old; median: 5years old) experiencing gastroenteritis symptoms from San Martín de los Andes, Argentina were tested for Norovirus using RT-PCR. Subsequently, Norovirus positive samples were analyzed by sequencing. Norovirus was found in four out of 10 samples received. Partial sequencing of the ORF2 was available for 3/4 samples: two samples belonged to genotype GII.4 and one to genotype GII.17 (Arg13099). Sequence analyses of the VP1 encoding region revealed that the GII.17 Argentinean strain presented characteristics from both, the new (cluster C), and older (cluster A and B) GII.17 strains. Phylogenetic and sequence analyses of the RdRp region showed that this strain was closely related to strains from genotypes GII.P3, GII.P13 and GII.P17; however, did not cluster within any of them. This study represents the first report of this emergent strain in South America, and presents further evidence of the genetic plasticity of the GII.17. •Novel GII.17 norovirus strain was detected in Argentina in 2015.•The VP1 genome sequence presented characteristics from new and older GII.17 strains.•This strain could represent a new RdRp genotype.
ISSN:1567-1348
1567-7257
DOI:10.1016/j.meegid.2016.11.026