Iron-sulfur clusters in mitochondrial metabolism: Multifaceted roles of a simple cofactor

Iron-sulfur metabolism is essential for cellular function and is a key process in mitochondria. In this review, we focus on the structure and assembly of mitochondrial iron-sulfur clusters and their roles in various metabolic processes that occur in mitochondria. Iron-sulfur clusters are crucial in...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2016-10, Vol.81 (10), p.1066-1080
Main Authors: Stiban, Johnny, So, Minyoung, Kaguni, Laurie S.
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Electron Transport Chain Complex Proteins - genetics
Electron Transport Chain Complex Proteins - metabolism
Health aspects
Humans
Iron
Iron (Nutrient)
Iron-Sulfur Proteins - genetics
Iron-Sulfur Proteins - metabolism
Life Sciences
Metabolism
Microbiology
Mitochondria - genetics
Mitochondria - metabolism
Mitochondrial Proteins - genetics
Mitochondrial Proteins - metabolism
Observations
Review
Sulfur
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Summary:Iron-sulfur metabolism is essential for cellular function and is a key process in mitochondria. In this review, we focus on the structure and assembly of mitochondrial iron-sulfur clusters and their roles in various metabolic processes that occur in mitochondria. Iron-sulfur clusters are crucial in mitochondrial respiration, in which they are required for the assembly, stability, and function of respiratory complexes I, II, and III. They also serve important functions in the citric acid cycle, DNA metabolism, and apoptosis. Whereas the identification of iron-sulfur containing proteins and their roles in numerous aspects of cellular function has been a long-standing research area, that in mitochondria is comparatively recent, and it is likely that their roles within mitochondria have been only partially revealed. We review the status of the field and provide examples of other cellular iron-sulfur proteins to highlight their multifarious roles.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297916100059