A novel sensitive and selective nanocomposite sensor for Doxorubicin based on Graphene Oxide and fluorescent [2]Rotaxane

A novel sensitive and selective nanocomposite sensor for Doxorubicin based on Graphene Oxide and fluorescent [2]Rotaxane is developed. The results show high sensitivity and selectivity toward DOX among many other antibiotics in the MeOH/H2O (3:2, v:v) solution. [Display omitted] •A novel sensitive a...

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Bibliographic Details
Published in:Sensors and actuators. B, Chemical Chemical, 2016-12, Vol.237, p.380-386
Main Authors: Bao, Xiaofeng, Shi, Jiaxin, Zhu, Jing, Wang, Xinlong
Format: Article
Language:English
Subjects:
Doxorubicin
Energy transfer
Fluorescence
Fretting
Graphene
Graphene oxide
Nanocomposite sensor
Oxides
Quenching
Rhodamine B
Rotaxane
Sensors
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Summary:A novel sensitive and selective nanocomposite sensor for Doxorubicin based on Graphene Oxide and fluorescent [2]Rotaxane is developed. The results show high sensitivity and selectivity toward DOX among many other antibiotics in the MeOH/H2O (3:2, v:v) solution. [Display omitted] •A novel sensitive and selective nanocomposite sensor for Doxorubicin based on Graphene Oxide and fluorescent [2]Rotaxane is developed.•The quencher properties of GO are analyzed by UV–vis and fluorescence spectra.•Fluorescence recovery can be observed after the addition of DOX.•The results of the fluorescence analysis demonstrate that the RhBPy-GO sensor exhibits high sensitivity and selectivity toward DOX alone among many other antibiotics. Graphene oxide (GO) displays advantageous characteristics as a quencher due to its excellent quenching capacity toward organic fluorescent molecules. In this paper, GO is used as a quencher of RhBPy [2]rotaxane based on the mechanism of fluorescence resonance energy transfer (FRET), and a GO-based fluorescent probe that allows rapid, sensitive and selective detection of doxorubicin (DOX) in a MeOH/H2O solution is reported. The results show that the efficient fluorescence quenching that occurs between GO and RhBPy [2]rotaxane is due to their strong noncovalent interactions via energy transfer, leading to very weak emission in the absence of DOX, while a strong red fluorescence is observed upon the addition of DOX into the RhBPy-GO solution. As a consequence, it is possible to employ the RhBPy-GO platform in DOX detection with high sensitivity and selectivity by monitoring changes in the fluorescence intensity of the MeOH/H2O (3:2, v: v) solution.
ISSN:0925-4005
1873-3077
DOI:10.1016/j.snb.2016.06.140