Hypolipidemic effect of β-caryophyllene to treat hyperlipidemic rats

The aim of this study was to evaluate the effect of β-caryophyllene on hypercholesterolemia using a model of hyperlipidemia induced by Triton WR-1339 in rats, as well as its possible effect on hepatic antioxidant enzymes. Thus, total cholesterol, triglycerides, low-density lipoprotein (LDL) choleste...

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 2017-02, Vol.390 (2), p.215-223
Main Authors: Baldissera, Matheus D., Souza, Carine F., Grando, Thirssa H., Doleski, Pedro H., Boligon, Aline A., Stefani, Lenita M., Monteiro, Silvia G.
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Biomarkers - blood
Biomedical and Life Sciences
Biomedicine
Catalase - metabolism
Disease Models, Animal
Female
Hydroxymethylglutaryl CoA Reductases - pharmacology
Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood
Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology
Hypercholesterolemia - blood
Hypercholesterolemia - chemically induced
Hypercholesterolemia - drug therapy
Lipids - blood
Liver - drug effects
Liver - metabolism
Neurosciences
Original Article
Oxidative Stress - drug effects
Pharmacology/Toxicology
Polyethylene Glycols
Rats, Wistar
Reactive Oxygen Species - metabolism
Sesquiterpenes - blood
Sesquiterpenes - pharmacology
Simvastatin - pharmacology
Superoxide Dismutase - metabolism
Thiobarbituric Acid Reactive Substances - metabolism
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Summary:The aim of this study was to evaluate the effect of β-caryophyllene on hypercholesterolemia using a model of hyperlipidemia induced by Triton WR-1339 in rats, as well as its possible effect on hepatic antioxidant enzymes. Thus, total cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol were measured in serum, while reactive oxygen species (ROS), thiobarbituric acid reactive substances (TBARS), hepatic 3-hydroxy-3-methylglutayl coenzyme A (HMG-CoA) reductase, superoxide dismutase (SOD), and catalase (CAT) activities were measured in the hepatic tissue. In addition, seric concentrations of β-caryophyllene were measured to perform correlation studies. Serum samples from hypercholesterolemic rats show higher ( p  
ISSN:0028-1298
1432-1912
DOI:10.1007/s00210-016-1326-3