Dynamic Changes in Liver Stiffness Measured by Transient Elastography Predict Clinical Outcomes Among Patients With Chronic Hepatitis B

• Published in: Journal of ultrasound in medicine 2017-02, Vol.36 (2), p.261-268
• Main Authors: Zeng, Jianyong, Cai, Shaohang, Liu, Jiajun, Xue, Xiulan, Wu, Xiaolu, Zheng, Caixia
• Format: Article
• Language: English
• Subjects: Adult; Antiviral Agents - therapeutic use; Elasticity Imaging Techniques; Female; Follow-Up Studies; gastrointestinal ultrasound; hepatitis B; Hepatitis B, Chronic - diagnostic imaging; Hepatitis B, Chronic - drug therapy; Hepatitis B, Chronic - pathology; histologic response; Humans; Liver - diagnostic imaging; Liver - pathology; Liver Cirrhosis - diagnostic imaging; Liver Cirrhosis - pathology; liver fibrosis; Male; METAVIR; Outcome Assessment (Health Care) - statistics & numerical data; Reproducibility of Results; Sensitivity and Specificity; transient elastography
• ISSN: 0278-4297; 1550-9613
• DOI: 10.7863/ultra.15.12054

Objectives We aimed to evaluate the validity of transient elastography in monitoring the antiviral outcomes in patients with chronic hepatitis B. Methods This study included 108 patients treated with nucleos(t)ide analogues and 67 patients treated with interferon (IFN). Liver biopsies were evaluated by the METAVIR score. Transient elastography was performed initially at baseline, 48 weeks, and 96 weeks. Liver tissue was obtained before and after 96 weeks of treatment. The area under the receiver operating characteristic curve was used to examine the diagnostic value of transient elastography in predicting and monitoring outcomes of antiviral treatment. Results The liver stiffness value correlated well with the baseline alanine aminotransferase level (r = 0.33; P