Atherosclerosis assessment and rheumatoid arthritis

Background and aim Rheumatoid arthritis is associated with increased morbidity and mortality due to atherosclerotic cardiovascular diseases. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme of phospholipase A2; it plays an important role in inflammation and atherosclerosis. Herein we a...

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Bibliographic Details
Published in:Zeitschrift für Rheumatologie 2018-05, Vol.77 (4), p.330-334
Main Authors: Bes, C., Gürel, S., Buğdaycı, G., Dikbaş, O., Soy, M.
Format: Article
Language:English
Subjects:
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - diagnosis
Atherosclerosis - complications
Atherosclerosis - diagnosis
C-Reactive Protein
Carotid Intima-Media Thickness
Diabetes Mellitus, Type 2 - complications
Humans
Immunology
Internal Medicine
Laboratory Medicine
Medicine
Medicine & Public Health
Originalie
Orthopedics
Rheumatology
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Summary:Background and aim Rheumatoid arthritis is associated with increased morbidity and mortality due to atherosclerotic cardiovascular diseases. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme of phospholipase A2; it plays an important role in inflammation and atherosclerosis. Herein we aimed to investigate whether Lp-PLA2 activity is associated with atherosclerosis in patients with rheumatoid arthritis and compare the Lp-PLA2 activity with carotid intima media thickness (CIMT). Patients and methods 25 patients with rheumatoid arthritis and 40 controls (20 patients with type 2 diabetes mellitus [DM] and 20 healthy controls) were included in the study. Frozen serum samples were used for analyzing Lp-PLA2 activity. Disease activity was calculated with DAS28 (Disease Activity Score 28) in the rheumatoid arthritis group. The mean CIMT was calculated in all participants. Results Lp-PLA2 activity was significantly higher in the DM group ( p  = 0.006) and LDL (Low density cholesterol levels) were lower in rheumatoid arthritis and healthy control groups compared with diabetics ( p  = 0.001 and p  = 0.029, respectively). The mean CIMT was significantly higher in patients with type 2 DM ( p  = 0.047). Conclusion Lp-PLA2 activity was not increased in the rheumatoid arthritis group when compared with healthy controls and the DM group. This result may be associated with low disease activity scores in patients with rheumatoid arthritis.
ISSN:0340-1855
1435-1250
DOI:10.1007/s00393-016-0239-3