Differential in vivo effects of H sub(3) receptor ligands in a new mouse dipsogenia model

The selective H sub(3) receptor agonist (R)- alpha -methylhistamine [(R)- alpha -MeHA] stimulates drinking in the adult rat. In the present study, we investigated the role of the H sub(3) receptor in mediating this behavior in a new dipsogenia model using the CD-1 mouse. In addition, the putative in...

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Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2002-06, Vol.72 (3), p.741-750
Main Authors: Fox, G B, Pan, J B, Esbenshade, T A, Bitner, R S, Nikkel, AL, Miller, T, Kang, Chae Hee, Bennani, Y L, Black, LA, Faghih, R, Hancock, A A, Decker, M W
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Language:English
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Summary:The selective H sub(3) receptor agonist (R)- alpha -methylhistamine [(R)- alpha -MeHA] stimulates drinking in the adult rat. In the present study, we investigated the role of the H sub(3) receptor in mediating this behavior in a new dipsogenia model using the CD-1 mouse. In addition, the putative inverse agonists ciproxifan, thioperamide and clobenpropit; the reported antagonist (1R,2R)4-[2-(5,5-dimethylhex-1-ynyl)cylopropyl]imidazole (GT-2331); and the putative neutral antagonist/weak partial agonist proxyfan were evaluated for possible differences in pharmacological activity in this new model. Water intake increased over baseline in a dose-related manner following intraperitoneal administration of 80, 160 or 240 mu mol/kg (R)- alpha -MeHA, but this effect was dependent on age (P30
ISSN:0091-3057