The efficacy of faropenem for patients with acute cystitis caused by extended spectrum β-lactamase producing Escherichia coli

• Published in: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2017-05, Vol.23 (5), p.336-338
• Main Authors: Fujino, Keiko, Hiyama, Yoshiki, MD, Uehara, Teruhisa, Ichihara, Koji, Hashimoto, Jiro, Fujii, Satoshi, Shinagawa, Masaaki, Takahashi, Satoshi, Masumori, Naoya
• Format: Article
• Language: English
• Subjects: Acute cystitis; Acute Disease; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents - therapeutic use; beta-Lactamases - metabolism; beta-Lactams - therapeutic use; Cystitis - drug therapy; Cystitis - microbiology; Escherichia coli; Escherichia coli - drug effects; Escherichia coli - metabolism; Escherichia coli Infections - drug therapy; Escherichia coli Infections - metabolism; Extended-spectrum β-lactamase (ESBL); Female; Hematology, Oncology and Palliative Medicine; Humans; Male; Middle Aged; Retrospective Studies; Young Adult
• ISSN: 1341-321X; 1437-7780
• DOI: 10.1016/j.jiac.2016.11.003

Abstract The number of patients with acute cystitis caused by extended spectrum β lactamase (ESBL)-producing Escherichia coli ( E. coli ) is increasing gradually. Although it is reported that ESBL-producing E. coli are sensitive to faropenem (FRPM), there are few clinical studies on the efficiency of FRPM against acute cystitis caused by the bacteria. Therefore, we retrospectively reviewed the medical charts of patients with acute cystitis caused by ESBL-producing E. coli who were treated with the oral antimicrobial agent faropenem (FRPM) in our institution from June 2011 to May 2015. Ten patients with acute cystitis caused by ESBL producing E. coli were treated with FRPM. Although clinical cure was achieved in 9 of them, it reoccurred in 3. This study revealed that the treatment regimen with FRPM for patients with acute cystitis caused by ESBL-producing E. coli is promising. However, a non-negligible number of recurrences were caused by ESBL-producing E. coli because of the nature of underlying diseases or pathologies in the urinary tract.