Trans- and paracellular calcium transport along the small and large intestine in horses

Intestinal calcium absorption plays a key role in the maintenance of calcium homeostasis and may either occur by paracellular or transcellular mechanisms. The horse has some unique peculiarities in calcium homeostasis compared to other species including a high absorptive capacity for calcium in the...

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Bibliographic Details
Published in:Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Molecular & integrative physiology, 2017-02, Vol.204, p.157-163
Main Authors: Wilkens, M.R., Marholt, L., Eigendorf, N., Muscher-Banse, A.S., Feige, K., Schröder, B., Breves, G., Cehak, A.
Format: Article
Language:English
Subjects:
Animals
BSPRY
Calbindin-D9k
Calcium - metabolism
Calmodulin
Female
Horse
Horses
Intestinal calcium transport
Intestine, Large - metabolism
Intestine, Small - metabolism
Ion Transport
Klotho
Male
PMCA1
TRPV6
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Summary:Intestinal calcium absorption plays a key role in the maintenance of calcium homeostasis and may either occur by paracellular or transcellular mechanisms. The horse has some unique peculiarities in calcium homeostasis compared to other species including a high absorptive capacity for calcium in the intestine, high plasma calcium concentrations, high renal excretion, and low plasma concentrations of vitamin D metabolites. So far, knowledge about the underlying mechanisms and the regulation of intestinal calcium absorption is still limited concerning this species. Several studies have documented that intestinal calcium transport in horses is not as dependent on vitamin D as in other species. However, published data on other potential regulatory mechanisms are still lacking. In the present study, paracellular and transcellular transport mechanisms for intestinal calcium transport along the intestinal axis were identified in horses using the Ussing chamber technique. Furthermore, the expression of respective transport proteins including transient receptor potential vanilloid member 6, calbindin-D9k and calcium ATPase type 1 in line with the determined calcium flux rates was documented. In respect to regulation of transepithelial calcium transport, novel regulatory proteins for maintaining calcium homeostasis such as B-box and SPRY-domain containing protein and calmodulin were investigated for the first time in equine intestinal tissues in this study. This provides the basis for a new approach for a better understanding of equine calcium homeostasis regulation.
ISSN:1095-6433
1531-4332
DOI:10.1016/j.cbpa.2016.11.020