Cognitive decline over time in adults with myotonic dystrophy type 1: A 9-year longitudinal study

Highlights • Verbal memory, visual attention, and processing speed abilities decline overtime. • Progression in cognitive scores correlates with age and disease duration, not with n CTG, muscular impairment or education. • The rate of cognitive decline is higher among DM1 patients with the late-onse...

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Bibliographic Details
Published in:Neuromuscular disorders : NMD 2017-01, Vol.27 (1), p.61-72
Main Authors: Gallais, Benjamin, Gagnon, Cynthia, Mathieu, Jean, Richer, Louis
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Attention
Cognitive ageing
Cognitive Aging - physiology
Cognitive Dysfunction - etiology
Cognitive Dysfunction - physiopathology
Disease Progression
Female
Humans
Longitudinal Studies
Male
Memory
Middle Aged
Myotonic Dystrophy - complications
Myotonic Dystrophy - physiopathology
Myotonic dystrophy type 1
Neurology
Neuromuscular diseases
Neuropsychology
Young Adult
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Summary:Highlights • Verbal memory, visual attention, and processing speed abilities decline overtime. • Progression in cognitive scores correlates with age and disease duration, not with n CTG, muscular impairment or education. • The rate of cognitive decline is higher among DM1 patients with the late-onset phenotype than in the adult phenotype.
ISSN:0960-8966
1873-2364
DOI:10.1016/j.nmd.2016.10.003