Multicellular Spheroids as a Model for Hypoxia-induced EMT

Oral cancer is aggressive and invasive. The 5-year survival rate is around 50% and has not improved in over 50 years. One-third of oral cancer patients develop local and/or regional tumor recurrence following treatment. We continue to use our multicellular spheroid (MCS) model to better understand h...

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Bibliographic Details
Published in:Anticancer research 2016-12, Vol.36 (12), p.6259-6264
Main Authors: Lee, Casey, Siu, Amanda, Ramos, Daniel M
Format: Article
Language:English
Subjects:
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Cell Hypoxia
Cell Line, Tumor
Epithelial-Mesenchymal Transition
Fibronectins - metabolism
Humans
Keratins - metabolism
Models, Theoretical
Spheroids, Cellular
Tongue Neoplasms - metabolism
Tongue Neoplasms - pathology
Vimentin - metabolism
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Summary:Oral cancer is aggressive and invasive. The 5-year survival rate is around 50% and has not improved in over 50 years. One-third of oral cancer patients develop local and/or regional tumor recurrence following treatment. We continue to use our multicellular spheroid (MCS) model to better understand how the extracellular matrix contributes to epithelial to mesenchymal transition and how hypoxia contributes to the progression of oral squamous cell carcinoma (SCC).
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.11220