Cordycepin attenuates traumatic brain injury-induced impairments of blood-brain barrier integrity in rats

Highlights • Cordycepin has neuroprotective effects against TBI. • Cordycepin attenuates blood-brain barrier disruption caused by TBI. • These effects may be linked to inhibition of inflammation and oxidative stress.

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Bibliographic Details
Published in:Brain research bulletin 2016-10, Vol.127, p.171-176
Main Authors: Yuan, Jing, Wang, Aihua, He, Yan, Si, Zhihua, Xu, Shan, Zhang, Shanchao, Wang, Kun, Wang, Dawei, Liu, Yiming
Format: Article
Language:English
Subjects:
Animals
Anti-inflammatory
Anti-oxidative
Blood-Brain Barrier - drug effects
Blood-Brain Barrier - metabolism
Blood-Brain Barrier - pathology
Blood-brain barrier integrity
Brain Injuries, Traumatic - drug therapy
Brain Injuries, Traumatic - metabolism
Brain Injuries, Traumatic - pathology
Cordycepin
Deoxyadenosines - pharmacology
Disease Models, Animal
Dose-Response Relationship, Drug
Interleukin-10 - metabolism
Interleukin-1beta - metabolism
Matrix Metalloproteinase 9 - metabolism
NADPH Oxidases - antagonists & inhibitors
NADPH Oxidases - metabolism
Neurology
Neuroprotective
Neuroprotective Agents - pharmacology
Nitric Oxide Synthase Type II - metabolism
Occludin - metabolism
Rats, Sprague-Dawley
Traumatic brain injury
Zonula Occludens-1 Protein - metabolism
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Description
Summary:Highlights • Cordycepin has neuroprotective effects against TBI. • Cordycepin attenuates blood-brain barrier disruption caused by TBI. • These effects may be linked to inhibition of inflammation and oxidative stress.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2016.09.010