Sleep and meal-time misalignment alters functional connectivity: a pilot resting-state study

Delayed sleep and meal times promote metabolic dysregulation and obesity. Altered coordination of sleeping and eating times may impact food-reward valuation and interoception in the brain, yet the independent and collective contributions of sleep and meal times are unknown. This randomized, in-patie...

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Bibliographic Details
Published in:International Journal of Obesity 2016-11, Vol.40 (11), p.1813-1816
Main Authors: Yoncheva, Y N, Castellanos, F X, Pizinger, T, Kovtun, K, St-Onge, M-P
Format: Article
Language:English
Subjects:
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Adult
Amygdala
Body Mass Index
Brain
Brain - physiology
Brain Mapping
Brain research
Circadian rhythms
Cross-Over Studies
Epidemiology
Feeding Behavior
Female
Food
Food habits
Functional magnetic resonance imaging
Health aspects
Health Promotion and Disease Prevention
Humans
Internal Medicine
Magnetic Resonance Imaging
Male
Meals - physiology
Medical imaging
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolic regulation
Metabolism
Misalignment
Neural networks
Neural Pathways
Neuroimaging
Nutrition
Obesity
Physiological aspects
Pilot Projects
Public Health
Reinforcement
Rest - physiology
Seeds
short-communication
Sleep
Sleep - physiology
Statistical analysis
United States
Valuation
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Summary:Delayed sleep and meal times promote metabolic dysregulation and obesity. Altered coordination of sleeping and eating times may impact food-reward valuation and interoception in the brain, yet the independent and collective contributions of sleep and meal times are unknown. This randomized, in-patient crossover study experimentally manipulates sleep and meal times while preserving sleep duration (7.05±0.44 h for 5 nights). Resting-state functional magnetic resonance imaging scans (2 × 5-minute runs) were obtained for four participants (three males; 25.3±4.6 years), each completing all study phases (normal sleep/normal meal; late sleep/normal meal; normal sleep/late meal; and late sleep/late meal). Normal mealtimes were 1, 5, 11 and 12.5 h after awakening; late mealtimes were 4.5, 8.5, 14.5 and 16 h after awakening. Seed-based resting-state functional connectivity (RSFC) was computed for a priori regions-of-interest (seeds) and contrasted across conditions. Statistically significant ( P
ISSN:0307-0565
1476-5497
DOI:10.1038/ijo.2016.132