Cryptotanshinone but not tanshinone IIA inhibits angiogenesis in vitro

In the course of screening of angiogenesis inhibitor from natural products, cryptotanshinone from Salvia miltiorrhiza was isolated as a potent small molecule inhibitor of angiogenesis. Cryptotanshinone inhibits bFGF-induced angiogenesis of BAECs at ten micromolar ranges in vitro without cytotoxicity...

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Bibliographic Details
Published in:Experimental & molecular medicine 2005-04, Vol.37 (2), p.133-137
Main Authors: Hur, Jong Moon, Shim, Joong Sup, Jung, Hye Jin, Kwon, Ho Jeong
Format: Article
Language:English
Subjects:
Salvia miltiorrhiza
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Summary:In the course of screening of angiogenesis inhibitor from natural products, cryptotanshinone from Salvia miltiorrhiza was isolated as a potent small molecule inhibitor of angiogenesis. Cryptotanshinone inhibits bFGF-induced angiogenesis of BAECs at ten micromolar ranges in vitro without cytotoxicity. Tanshinone IIA, another tanshinone isolated from S. miltiorrhiza, which is structurally very similar to cryptotanshinone except C-15 position of dihydrofuran ring does not inhibit angiogenesis induced by bFGF. These results demonstrate that cryptotanshinone is a new anti-angiogenic agent and double bond at C-15 position of the dihydrofuran ring plays a crucial role in the activity.
ISSN:2092-6413
1226-3613
2092-6413
DOI:10.1038/emm.2005.18