IMPACT OF 4-NONYLPHENOL ON TESTOSTERONE PRODUCTION IN MICE LEYDIG CELLS

Nonylphenol (NP) is an important environmental toxicant and potential endocrine disrupting chemical. It is also the primary final biodegradation product of nonylphenol polyethoxylate, a non-ionic surfactant that is frequently incorporated into detergent formulation. Several studies have reported adv...

Full description

Saved in:
Bibliographic Details
Published in:Journal of microbiology, biotechnology and food sciences biotechnology and food sciences, 2015-02, Vol.4 (special issue 2 (Biotechnology)), p.42-44
Main Authors: Jambor, Tomáš, Lukáčová, Jana, Tvrdá, Eva, Kňažická, Zuzana, Forgács, Zsolt, Lukáč, Norbert
Format: Article
Language:English
Subjects:
Biosynthesis
Enzymes
Food
Hormones
Male reproductive system
Physiology
Polyvinyl chloride
Steroids
Surfactants
Testes
Testosterone
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nonylphenol (NP) is an important environmental toxicant and potential endocrine disrupting chemical. It is also the primary final biodegradation product of nonylphenol polyethoxylate, a non-ionic surfactant that is frequently incorporated into detergent formulation. Several studies have reported adverse effects of NP on the male reproductive system, including hormonal changes and testicular abnormalities. However, its mechanisms are not clearly understood. In the present study, experiments were performed to examine the effects of 4-nonylphenol on the testosterone production in mice Leydig cells. Interstitial (Leydig) cells were cultured with addition of 0.04, 0.2, 1.0, 2.5 and 5 μg/mL of 4-nonylphenol and compared with control. Concentrations of testosterone in the media were determined using enzyme linked immunosorbent assay (ELISA). Hormone production significantly (P
ISSN:1338-5178
1338-5178
DOI:10.15414/jmbfs.2015.4.special2.42-44