Morroniside promotes angiogenesis and further improves microvascular circulation after focal cerebral ischemia/reperfusion

Highlights • Morroniside promotes angiogenesis after focal cerebral ischemia/reperfusion. • Newly generated vessels enhances rCBF and improves microvascular circulation. • Angiogenic effect of morroniside is mediated by the ephrinB2/VEGFR2 signaling. • Morroniside eventually reduces the infarct volu...

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Bibliographic Details
Published in:Brain research bulletin 2016-10, Vol.127, p.111-118
Main Authors: Liu, Tingting, Xiang, Benxu, Guo, Deyu, Sun, Fangling, Wei, Renping, Zhang, Guoxing, Ai, Houxi, Tian, Xin, Zhu, Zixin, Zheng, Wenrong, Wang, Yufeng, Wang, Wen
Format: Article
Language:English
Subjects:
Angiogenesis
Angiogenesis Inducing Agents - pharmacology
Animals
Brain - blood supply
Brain - drug effects
Brain - pathology
Brain - physiopathology
Brain Ischemia - drug therapy
Brain Ischemia - pathology
Brain Ischemia - physiopathology
Cerebral blood flow
Cerebrovascular Circulation - drug effects
Cerebrovascular Circulation - physiology
Disease Models, Animal
Ephrin-B2 - metabolism
EphrinB2/VEGFR2 signaling
Glycosides - pharmacology
Ischemic stroke
Male
Microvessels - drug effects
Microvessels - pathology
Microvessels - physiopathology
Morroniside
Neovascularization, Physiologic - drug effects
Neovascularization, Physiologic - physiology
Neurology
Random Allocation
Rats, Sprague-Dawley
Reperfusion Injury - drug therapy
Reperfusion Injury - pathology
Reperfusion Injury - physiopathology
Stroke - drug therapy
Stroke - pathology
Stroke - physiopathology
Vascular Endothelial Growth Factor Receptor-2 - metabolism
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Summary:Highlights • Morroniside promotes angiogenesis after focal cerebral ischemia/reperfusion. • Newly generated vessels enhances rCBF and improves microvascular circulation. • Angiogenic effect of morroniside is mediated by the ephrinB2/VEGFR2 signaling. • Morroniside eventually reduces the infarct volume and improves functional recovery.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2016.09.004