Involvement of dihydropyridine-sensitive calcium channels in high asynchrony of transmitter release in neuromuscular synapses of newborn rats

Experiments on neuromuscular synapses of rats at different stages of ontogenesis have been performed. It has been found that one of the reasons of higher asynchrony of the release of single quanta of acetylcholine in the synapses of newborn animals is the activity of the presynaptic dihydropyridine-...

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Bibliographic Details
Published in:Doklady. Biological sciences 2016-09, Vol.470 (1), p.220-223
Main Authors: Khuzakhmetova, V. F., Nurullin, L. F., Bukharaeva, E. A., Nikolsky, E. E.
Format: Article
Language:English
Subjects:
Acetylcholine - metabolism
Animals
Animals, Newborn
Biomedical and Life Sciences
Calcium Channel Blockers - administration & dosage
Calcium Channels, L-Type - drug effects
Calcium Channels, L-Type - physiology
Dihydropyridines - administration & dosage
Dose-Response Relationship, Drug
Evolutionary Biology
In Vitro Techniques
Ion Channel Gating - drug effects
Ion Channel Gating - physiology
Life Sciences
Neurogenesis - physiology
Neuromuscular Junction - drug effects
Neuromuscular Junction - physiology
Neurotransmitter Agents - metabolism
Physiology
Plant Sciences
Rats
Rats, Wistar
Synaptic Transmission - drug effects
Synaptic Transmission - physiology
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Summary:Experiments on neuromuscular synapses of rats at different stages of ontogenesis have been performed. It has been found that one of the reasons of higher asynchrony of the release of single quanta of acetylcholine in the synapses of newborn animals is the activity of the presynaptic dihydropyridine-sensitive calcium channels of the L-type.
ISSN:0012-4966
1608-3105
DOI:10.1134/S0012496616050124