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Neuropsychological Outcomes in Extremely Preterm Preschoolers Exposed to Tiered Low Oxygen Targets: An Observational Study
An observational study of neuropsychological outcomes at preschool age of tiered lowered oxygen (O2) saturation targets in extremely preterm neonates. We studied 111 three-year-olds born
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| Published in: | Journal of the International Neuropsychological Society 2016-03, Vol.22 (3), p.322-331 |
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| container_end_page | 331 |
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| container_title | Journal of the International Neuropsychological Society |
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| creator | Baron, Ida Sue Weiss, Brandi A. Baker, Robin Ahronovich, Margot D. Litman, Fern R. Baveja, Rajiv |
| description | An observational study of neuropsychological outcomes at preschool age of tiered lowered oxygen (O2) saturation targets in extremely preterm neonates. We studied 111 three-year-olds born |
| doi_str_mv | 10.1017/S1355617715001186 |
| format | article |
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We studied 111 three-year-olds born <28 weeks’ gestational age. Fifty-nine participants born in 2009–2010 during a time-limited quality improvement initiative each received three-tiered stratification of oxygen rates (83–93% until age 32 weeks, 85–95% until age 35 weeks, and 95% after age 35 weeks), the TieredO2 group. Comparisons were made with 52 participants born in 2007–2008 when pre-initiative saturation targets were non-tiered at 89–100%, the Non-tieredO2 group. Neuropsychological domains included general intellectual, executive, attention, language, visuoperceptual, visual-motor, and fine and gross motor functioning. Descriptive and inferential analyses were conducted. Group comparisons were not statistically significant. Descriptively, the TieredO2 group had better general intellectual, executive function, visual-motor, and motor performance and the Non-tieredO2 group had better language performance. Cohen’s d and confidence intervals around d were in similar direction and magnitude across measures. A large effect size was found for recall of digits-forward in participants born at 23 and 24 weeks’ gestation, d=0.99 and 1.46, respectively. Better TieredO2 outcomes in all domains except language suggests that the tiered oxygen saturation target method is not harmful and merits further investigation through further studies. Benefit in auditory attention appeared greatest in those born at 23 and 24 weeks. Participants in the tiered oxygen saturation group also had fewer ventilation days and a lower incidence of bronchopulmonary dysplasia, perhaps explanatory for these neuropsychological outcomes at age 3. (JINS, 2015, 21, 322–331)</description><identifier>ISSN: 1355-6177</identifier><identifier>EISSN: 1469-7661</identifier><identifier>DOI: 10.1017/S1355617715001186</identifier><identifier>PMID: 26646724</identifier><language>eng</language><publisher>New York, USA: Cambridge University Press</publisher><subject>Age Factors ; Analysis of Variance ; Attention - physiology ; Child Development - physiology ; Child, Preschool ; Executive Function - physiology ; Female ; Gestational Age ; Humans ; Infant, Extremely Premature - physiology ; Infant, Newborn ; Male ; Mental Recall - physiology ; Mortality ; Motor Activity - physiology ; Neuropsychology ; Newborn babies ; Oxygen - administration & dosage ; Oxygen saturation ; Premature babies ; Premature birth ; Preschool children ; Psychomotor Performance - physiology ; Pulse oximetry ; Surfactants ; Visual Perception - physiology</subject><ispartof>Journal of the International Neuropsychological Society, 2016-03, Vol.22 (3), p.322-331</ispartof><rights>Copyright © The International Neuropsychological Society 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-f5ab0c029c405d636dabebf3f82026b6d1dae560264887f491ba82d2c4f5e91f3</citedby><cites>FETCH-LOGICAL-c476t-f5ab0c029c405d636dabebf3f82026b6d1dae560264887f491ba82d2c4f5e91f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S1355617715001186/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,72960</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26646724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baron, Ida Sue</creatorcontrib><creatorcontrib>Weiss, Brandi A.</creatorcontrib><creatorcontrib>Baker, Robin</creatorcontrib><creatorcontrib>Ahronovich, Margot D.</creatorcontrib><creatorcontrib>Litman, Fern R.</creatorcontrib><creatorcontrib>Baveja, Rajiv</creatorcontrib><title>Neuropsychological Outcomes in Extremely Preterm Preschoolers Exposed to Tiered Low Oxygen Targets: An Observational Study</title><title>Journal of the International Neuropsychological Society</title><addtitle>J Int Neuropsychol Soc</addtitle><description>An observational study of neuropsychological outcomes at preschool age of tiered lowered oxygen (O2) saturation targets in extremely preterm neonates. We studied 111 three-year-olds born <28 weeks’ gestational age. Fifty-nine participants born in 2009–2010 during a time-limited quality improvement initiative each received three-tiered stratification of oxygen rates (83–93% until age 32 weeks, 85–95% until age 35 weeks, and 95% after age 35 weeks), the TieredO2 group. Comparisons were made with 52 participants born in 2007–2008 when pre-initiative saturation targets were non-tiered at 89–100%, the Non-tieredO2 group. Neuropsychological domains included general intellectual, executive, attention, language, visuoperceptual, visual-motor, and fine and gross motor functioning. Descriptive and inferential analyses were conducted. Group comparisons were not statistically significant. Descriptively, the TieredO2 group had better general intellectual, executive function, visual-motor, and motor performance and the Non-tieredO2 group had better language performance. Cohen’s d and confidence intervals around d were in similar direction and magnitude across measures. A large effect size was found for recall of digits-forward in participants born at 23 and 24 weeks’ gestation, d=0.99 and 1.46, respectively. Better TieredO2 outcomes in all domains except language suggests that the tiered oxygen saturation target method is not harmful and merits further investigation through further studies. Benefit in auditory attention appeared greatest in those born at 23 and 24 weeks. Participants in the tiered oxygen saturation group also had fewer ventilation days and a lower incidence of bronchopulmonary dysplasia, perhaps explanatory for these neuropsychological outcomes at age 3. (JINS, 2015, 21, 322–331)</description><subject>Age Factors</subject><subject>Analysis of Variance</subject><subject>Attention - physiology</subject><subject>Child Development - physiology</subject><subject>Child, Preschool</subject><subject>Executive Function - physiology</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant, Extremely Premature - physiology</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Mental Recall - physiology</subject><subject>Mortality</subject><subject>Motor Activity - physiology</subject><subject>Neuropsychology</subject><subject>Newborn babies</subject><subject>Oxygen - administration & dosage</subject><subject>Oxygen saturation</subject><subject>Premature babies</subject><subject>Premature birth</subject><subject>Preschool children</subject><subject>Psychomotor Performance - physiology</subject><subject>Pulse oximetry</subject><subject>Surfactants</subject><subject>Visual Perception - physiology</subject><issn>1355-6177</issn><issn>1469-7661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkUGL1EAQhRtR3HX0B3iRBi97iXYlnerE27LsqjA4wo7n0OmujFmS9Njd0Y2_3h5mFFHEUz14X72ieIw9B_EKBKjXt1CUJYJSUAoBUOEDdg4S60whwsOkk50d_DP2JIS7xBQgxGN2liNKVLk8Z98_0OzdPizmsxvcrjd64Js5GjdS4P3Er--jp5GGhX_0FMmPhxkS7AbyIdl7F8jy6Pi2J5_U2n3jm_tlRxPfar-jGN7wy4lv2kD-q469m9KF2zjb5Sl71Okh0LPTXLFPN9fbq3fZevP2_dXlOjNSYcy6UrfCiLw2UpQWC7S6pbYruioXObZowWoqMWlZVaqTNbS6ym1uZFdSDV2xYhfH3L13X2YKsRn7YGgY9ERuDg1UEqVALNT_UYV1XRW5hIS-_AO9c7NPzx0pAVWZyBWDI2W8C8FT1-x9P2q_NCCaQ4fNXx2mnRen5Lkdyf7a-FlaAopTqB5b39sd_Xb7n7E_ADDZptU</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Baron, Ida Sue</creator><creator>Weiss, Brandi A.</creator><creator>Baker, Robin</creator><creator>Ahronovich, Margot D.</creator><creator>Litman, Fern R.</creator><creator>Baveja, Rajiv</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20160301</creationdate><title>Neuropsychological Outcomes in Extremely Preterm Preschoolers Exposed to Tiered Low Oxygen Targets: An Observational Study</title><author>Baron, Ida Sue ; 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Cohen’s d and confidence intervals around d were in similar direction and magnitude across measures. A large effect size was found for recall of digits-forward in participants born at 23 and 24 weeks’ gestation, d=0.99 and 1.46, respectively. Better TieredO2 outcomes in all domains except language suggests that the tiered oxygen saturation target method is not harmful and merits further investigation through further studies. Benefit in auditory attention appeared greatest in those born at 23 and 24 weeks. Participants in the tiered oxygen saturation group also had fewer ventilation days and a lower incidence of bronchopulmonary dysplasia, perhaps explanatory for these neuropsychological outcomes at age 3. (JINS, 2015, 21, 322–331)</abstract><cop>New York, USA</cop><pub>Cambridge University Press</pub><pmid>26646724</pmid><doi>10.1017/S1355617715001186</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of the International Neuropsychological Society, 2016-03, Vol.22 (3), p.322-331 |
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| language | eng |
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| source | Cambridge University Press |
| subjects | Age Factors Analysis of Variance Attention - physiology Child Development - physiology Child, Preschool Executive Function - physiology Female Gestational Age Humans Infant, Extremely Premature - physiology Infant, Newborn Male Mental Recall - physiology Mortality Motor Activity - physiology Neuropsychology Newborn babies Oxygen - administration & dosage Oxygen saturation Premature babies Premature birth Preschool children Psychomotor Performance - physiology Pulse oximetry Surfactants Visual Perception - physiology |
| title | Neuropsychological Outcomes in Extremely Preterm Preschoolers Exposed to Tiered Low Oxygen Targets: An Observational Study |
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