Pulmonary anthracosis mimicking lung metastases in pediatric rhabdomyosarcoma

Although childhood rhabdomyosarcoma typically metastasizes to lungs, various processes may mimic metastatic etiology. Described herein is the case of an 8½‐year‐old boy with orbital embryonal rhabdomyosarcoma (RME) in whom three small foci were detected within both lungs on computed tomography. The...

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Bibliographic Details
Published in:Pediatrics international 2016-10, Vol.58 (10), p.1066-1068
Main Authors: Karpinsky, Gabrielle, Krawczyk, Malgorzata Anna, Fatyga, Aleksandra, Izycka‐Swieszewska, Ewa, Dubaniewicz‐Wybieralska, Miroslawa, Szmyd, Dagmara, Luboch‐Furmanczyk, Monika, Bien, Ewa
Format: Article
Language:English
Subjects:
Anthracosis - complications
Anthracosis - diagnosis
benign lung lesion
Biopsy
Cancer
Chemotherapy
Child
Children
Computed tomography
Diagnosis, Differential
embryonal rhabdomyosarcoma
Etiology
Histopathology
Humans
Lesions
Lung - diagnostic imaging
Lung cancer
lung metastasis
Lung Neoplasms - diagnosis
Lung nodules
Lungs
Lymph nodes
Magnetic Resonance Imaging
Male
Metastases
Metastasis
Mimicry
Orbital Neoplasms - complications
Orbital Neoplasms - diagnosis
Parenchyma
Pediatrics
pulmonary anthracosis
Rhabdomyosarcoma
Rhabdomyosarcoma, Embryonal - complications
Rhabdomyosarcoma, Embryonal - diagnosis
Smoking
Tomography
Tomography, X-Ray Computed
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Description
Summary:Although childhood rhabdomyosarcoma typically metastasizes to lungs, various processes may mimic metastatic etiology. Described herein is the case of an 8½‐year‐old boy with orbital embryonal rhabdomyosarcoma (RME) in whom three small foci were detected within both lungs on computed tomography. The lesion number and size, however, did not fulfil the Cooperative Weichteilsarkom Study Group 2006 protocol criteria for lung metastasis. Chemotherapy for localized RME produced primary tumor regression and vanishing of the left lung lesion. Two lesions in the right lung remained unchanged. On thoracoscopy multiple minute nodules disseminated in both lungs were detected. Histopathology excluded RME spread but indicated anthracosis in the lung parenchyma and intrapulmonary lymph nodes. Heavy smoking by parents and previous home furnace combustion appeared to be predisposing factors. Uncommon non‐malignant intrapulmonary diseases, including anthracosis, should be considered when staging pediatric cancer.
ISSN:1328-8067
1442-200X
DOI:10.1111/ped.13058