Poly(polyol sebacate) Elastomers as Coatings for Metallic Coronary Stents

• Published in: Macromolecular bioscience 2016-11, Vol.16 (11), p.1678-1692
• Main Authors: Navarro, Lucila, Mogosanu, Diana-Elena, de Jong, Thijs, Bakker, Astrid D., Schaubroeck, David, Luna, Julio, Rintoul, Ignacio, Vanfleteren, Jan, Dubruel, Peter
• Format: Article
• Language: English
• Subjects: Adipose Tissue - cytology; Adipose Tissue - metabolism; Adult; biocompatible; Coated Materials, Biocompatible - chemistry; Coated Materials, Biocompatible - pharmacology; coatings; Drug-Eluting Stents; Female; Humans; Materials Testing; metallic stents; Middle Aged; poly(polyol-sebacate)s; Polymers; Polymers - chemistry; Polymers - pharmacology; Stem Cells - cytology; Stem Cells - metabolism; Stents
• ISSN: 1616-5187; 1616-5195
• DOI: 10.1002/mabi.201600105

Biocompatible polymeric coatings for metallic stents are desired, as currently used materials present limitations such as deformation during degradation and exponential loss of mechanical properties after implantation. These concerns, together with the present risks of the drug‐eluting stents, namely, thrombosis and restenosis, require new materials to be studied. For this purpose, novel poly(polyol sebacate)‐derived polymers are investigated as coatings for metallic stents. All pre‐polymers reveal a low molecular weight between 3000 and 18 000 g mol−1. The cured polymers range from flexible to more rigid, with E‐modulus between 0.6 and 3.8 MPa. Their advantages include straightforward synthesis, biodegradability, easy processing through different scaffolding techniques, and easy transfer to industrial production. Furthermore, electrospraying and dip‐coating procedures are used as proof‐of‐concept to create coatings on metallic stents. Biocompatibility tests using adipose stem cells lead to promising results for the use of these materials as coatings for metallic coronary stents. Novel poly(polyol sebacate)‐derived pre‐polymers are prepared via microwave irradiation and bulk polymerization. These pre‐polymers are cross‐linked and characterized as being flexible and biocompatible with human adipose‐derived stem cells. Easily processable, the materials are investigated as coatings for metallic coronary stent applications. Two techniques are employed for this purpose, namely, dip‐coating and electrospraying.