Genetic markers associated with cutaneous adverse drug reactions to allopurinol: a systematic review

Pharmacogenomic markers in the HLA coding genes have been associated with drug hypersensitivity of multiple drugs, including allopurinol. In this systematic review, we summarize the pharmacogenomic evidence available regarding allopurinol-induced cutaneous adverse drug reactions (cADRs). We found th...

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Bibliographic Details
Published in:Pharmacogenomics 2015-05, Vol.16 (7), p.755-767
Main Authors: Jarjour, Samantha, Barrette, Mathieu, Normand, Valérie, Rouleau, Jean Lucien, Dubé, Marie-Pierre, de Denus, Simon
Format: Article
Language:English
Subjects:
adverse reaction
allopurinol
Allopurinol - adverse effects
Analysis
Care and treatment
Complications and side effects
Drug Eruptions - diagnosis
Drug Eruptions - genetics
drug-induced hypersensitivity syndrome
Drug-Related Side Effects and Adverse Reactions - diagnosis
Drug-Related Side Effects and Adverse Reactions - genetics
Genetic Markers - drug effects
Genetic Markers - genetics
Genome-Wide Association Study - methods
Genome-Wide Association Study - trends
Gout suppressants
HLA
HLA antigens
HLA Antigens - genetics
Humans
Hyperuricemia
Mortality
Pharmacogenetics - methods
Pharmacogenetics - trends
Pharmacogenomics
Polymorphism, Single Nucleotide - genetics
Prevention
rash
safety
Stevens-Johnson syndrome
toxic epidermal necrolysis
United States
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Description
Summary:Pharmacogenomic markers in the HLA coding genes have been associated with drug hypersensitivity of multiple drugs, including allopurinol. In this systematic review, we summarize the pharmacogenomic evidence available regarding allopurinol-induced cutaneous adverse drug reactions (cADRs). We found that the allele was significantly associated with the risk of severe cADRs in the Han Chinese, Korean, Thai, Japanese and European populations. The association between less severe cADRs and was less consistent. All SNPs identified in genome-wide association studies of common variants were also located in or nearby . Future studies should focus on more common but less severe allopurinol-induced cADRs, as well as the potential role of rare variants as predictors of these cADRs.
ISSN:1462-2416
1744-8042
DOI:10.2217/pgs.15.21