Safe and symptomatic medicinal use of surface-functionalized Mn3O4 nanoparticles for hyperbilirubinemia treatment in mice

Testing the potential of citrate-capped Mn3O4 nanoparticles (NPs) as a therapeutic agent for alternative rapid treatment of hyperbilirubinemia through direct removal of bilirubin (BR) from blood in mice. NPs were synthesized and the mechanism of BR degradation in presence and absence of biological m...

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Published in:Nanomedicine (London, England) England), 2015-08, Vol.10 (15), p.2349-2363
Main Authors: Polley, Nabarun, Saha, Srimoyee, Adhikari, Aniruddha, Banerjee, Somtirtha, Darbar, Soumendra, Das, Sukhen, Pal, Samir Kumar
Format: Article
Language:English
Subjects:
Animals
Circular Dichroism
Hyperbilirubinemia - drug therapy
Hyperbilirubinemia - pathology
Manganese Compounds - therapeutic use
Mice
Nanoparticles
Oxides - therapeutic use
Surface Properties
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container_issue 15
container_start_page 2349
container_title Nanomedicine (London, England)
container_volume 10
creator Polley, Nabarun
Saha, Srimoyee
Adhikari, Aniruddha
Banerjee, Somtirtha
Darbar, Soumendra
Das, Sukhen
Pal, Samir Kumar
description Testing the potential of citrate-capped Mn3O4 nanoparticles (NPs) as a therapeutic agent for alternative rapid treatment of hyperbilirubinemia through direct removal of bilirubin (BR) from blood in mice. NPs were synthesized and the mechanism of BR degradation in presence and absence of biological macromolecules were characterized in vitro. To test the in vivo BR degradation ability of NPs, CCl4-intoxicated mice were intraperitoneally injected with NPs. We demonstrated ultrahigh efficacy of the NPs in symptomatic treatment of hyperbilirubinemia for rapid reduction of BR in mice compared with conventional medicine silymarin without any toxicological implications. These findings may pave the way for practical clinical use of the NPs as safe medication of hyperbilirubinemia in human subjects.
doi_str_mv 10.2217/nnm.15.83
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subjects Animals
Circular Dichroism
Hyperbilirubinemia - drug therapy
Hyperbilirubinemia - pathology
Manganese Compounds - therapeutic use
Mice
Nanoparticles
Oxides - therapeutic use
Surface Properties
title Safe and symptomatic medicinal use of surface-functionalized Mn3O4 nanoparticles for hyperbilirubinemia treatment in mice
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