Effects of Bed-Rest on Urea and Creatinine: Correlation with Changes in Fat-Free Mass: e108805

Background Bed-rest experiments are designed for investigation on catabolic effects of hypokinetic conditions and/or for microgravity simulation in on-ground aerospace research. Bed-rest effects include a reduction in fat-free mass and muscle mass. Urea and creatinine are catabolites of endogenous p...

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Published in:PloS one 2014-09, Vol.9 (9)
Main Authors: Bilancio, Giancarlo, Lombardi, Cinzia, Pisot, Rado, Santo, Natale GDe, Cavallo, Pierpaolo, Cirillo, Massimo
Format: Article
Language:English
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Summary:Background Bed-rest experiments are designed for investigation on catabolic effects of hypokinetic conditions and/or for microgravity simulation in on-ground aerospace research. Bed-rest effects include a reduction in fat-free mass and muscle mass. Urea and creatinine are catabolites of endogenous protein and of muscular energetic metabolism which are excreted mainly by the kidney. The study investigated on urea, creatinine, and kidney function during bed-rest. Methods Twenty healthy young men underwent a 7-day adaptation period (day-6 to day-0) and a 35-day bed-rest experiment (day1 to day35) during normocaloric diet. Urine were collected from day-3 to day0 (baseline) and from day1 to day35. Blood samples and anthropometrical data were collected at day0 (baseline) and bed-rest days 7, 14, 21, 28, and 35. Results Bed-rest reduced plasma volume, weight, fat-free mass, and muscle mass (P
ISSN:1932-6203
DOI:10.1371/journal.pone.0108805