Assessment of the lung toxicity of copper oxide nanoparticles: current status

Copper oxide nanoparticles (CuO NPs) are being used in several industrial and commercial products. Inhalation is one of the most significant routes of metal oxide NP exposure. Hence, the toxicity of CuO NPs in lung tissues is of great concern. studies have indicated that CuO NPs induce cytotoxicity,...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2015-08, Vol.10 (15), p.2365-2377
Main Authors: Ahamed, Maqusood, Akhtar, Mohd Javed, Alhadlaq, Hisham A, Alrokayan, Salman A
Format: Article
Language:English
Subjects:
apoptosis
Autophagy
Cell Line
Copper - toxicity
copper oxide nanoparticles
Copper oxides
Cu ions
Health aspects
Humans
In Vitro Techniques
Lung - drug effects
Lung diseases
lung toxicity
Nanoparticles
Nanoparticles - toxicity
Oxidative Stress
Risk factors
ROS
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Summary:Copper oxide nanoparticles (CuO NPs) are being used in several industrial and commercial products. Inhalation is one of the most significant routes of metal oxide NP exposure. Hence, the toxicity of CuO NPs in lung tissues is of great concern. studies have indicated that CuO NPs induce cytotoxicity, oxidative stress and genetic toxicity in cultivated human lung cells. Leaching of Cu ions, reactive oxygen species generation and autophagy appear to be the underlying mechanisms of Cu NP toxicity in lung cells. studies on the lung toxicity of CuO NPs are largely lacking. Some studies have shown that intratracheal instillation of CuO NPs induced oxidative stress, inflammation and neoplastic lesions in rats. This review critically assessed the current findings of the toxicity of CuO NPs in the lung.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm.15.72