Digit Span Performance in Children with Dystrophinopathy: A Verbal Span or Working Memory Contribution?

Objectives: In a large cohort of boys with dystrophinopathies and their unaffected siblings, we examined whether consistently observed performance on digit span is due primarily to a verbal span or executive deficit. We additionally assessed whether digit span performance contributed to the observed...

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Bibliographic Details
Published in:Journal of the International Neuropsychological Society 2016-08, Vol.22 (7), p.777-784
Main Authors: Leaffer, Emily B., Fee, Robert J., Hinton, Veronica J.
Format: Article
Language:English
Subjects:
Adolescent
Child
Children & youth
Cognition & reasoning
Cognitive ability
Cognitive Dysfunction - etiology
Cognitive Dysfunction - physiopathology
Executive Function - physiology
Humans
Hypotheses
Male
Memory
Memory, Short-Term - physiology
Muscular Dystrophies - complications
Muscular Dystrophies - physiopathology
Muscular dystrophy
Mutation
Reading
Siblings
Skills
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Summary:Objectives: In a large cohort of boys with dystrophinopathies and their unaffected siblings, we examined whether consistently observed performance on digit span is due primarily to a verbal span or executive deficit. We additionally assessed whether digit span performance contributed to the observed variability in reading performance noted in this population. Methods: Performance of 170 boys with dystrophinopathy was compared to 95 unaffected sibling controls on measures of verbal function, reading, and digit span. Maximum digit span forward (DSF) and backward (DSB) lengths were converted to Z-scores using normative data. Independent sample t tests, analysis of variance, and hierarchical multiple regression were run (α=0.05). Results: Probands performed worse than controls on digit span, even after accounting for differences in general verbal function (p
ISSN:1355-6177
1469-7661
DOI:10.1017/S1355617716000461