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Codelivery of dual drugs from polymeric micelles for simultaneous targeting of both cancer cells and cancer stem cells
Phenformin-loaded micelles (Phen M) were used in combination with gemcitabine-loaded micelles (Gem M) to study their combined effect against H460 human lung cancer cells and cancer stem cells (CSCs) and . Gem M and Phen M were prepared via self-assembly of a mixture of a diblock copolymer of PEG and...
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| Published in: | Nanomedicine (London, England) England), 2015-09, Vol.10 (18), p.2819-2832 |
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| Main Authors: | , , , , , |
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| container_issue | 18 |
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| container_title | Nanomedicine (London, England) |
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| creator | Krishnamurthy, Sangeetha Ng, Victor WL Gao, Shujun Tan, Min-Han Hedrick, James L Yang, Yi Yan |
| description | Phenformin-loaded micelles (Phen M) were used in combination with gemcitabine-loaded micelles (Gem M) to study their combined effect against H460 human lung cancer cells and cancer stem cells (CSCs)
and
.
Gem M and Phen M were prepared via self-assembly of a mixture of a diblock copolymer of PEG and urea-functionalized polycarbonate (PEG-PUC) and a diblock copolymer of PEG and acid-functionalized polycarbonate (PEG-PAC) through hydrogen bonding and ionic interactions. Gem M and Phen M were characterized and tested for efficacy both
and
against cancer cells and CSCs.
The combination of Gem M/Phen M exhibited higher cytotoxicity against CSCs and non-CSCs than Gem M and Phen M alone, and showed significant cell cycle growth arrest
. The combination therapy had superior tumor suppression and apoptosis
without inducing toxicity to liver and kidney.
The combination of Gem M and Phen M may be potentially used in lung cancer therapy. |
| doi_str_mv | 10.2217/nnm.15.109 |
| format | article |
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and
.
Gem M and Phen M were prepared via self-assembly of a mixture of a diblock copolymer of PEG and urea-functionalized polycarbonate (PEG-PUC) and a diblock copolymer of PEG and acid-functionalized polycarbonate (PEG-PAC) through hydrogen bonding and ionic interactions. Gem M and Phen M were characterized and tested for efficacy both
and
against cancer cells and CSCs.
The combination of Gem M/Phen M exhibited higher cytotoxicity against CSCs and non-CSCs than Gem M and Phen M alone, and showed significant cell cycle growth arrest
. The combination therapy had superior tumor suppression and apoptosis
without inducing toxicity to liver and kidney.
The combination of Gem M and Phen M may be potentially used in lung cancer therapy.</description><identifier>ISSN: 1743-5889</identifier><identifier>EISSN: 1748-6963</identifier><identifier>DOI: 10.2217/nnm.15.109</identifier><identifier>PMID: 26377155</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject><![CDATA[Analysis ; Animals ; Antimetabolites, Antineoplastic - administration & dosage ; Antimetabolites, Antineoplastic - pharmacology ; Antimetabolites, Antineoplastic - therapeutic use ; Antineoplastic Combined Chemotherapy Protocols - administration & dosage ; Antineoplastic Combined Chemotherapy Protocols - pharmacology ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; cancer stem cells ; Care and treatment ; Cell Line, Tumor ; Cell Proliferation - drug effects ; codelivery ; Deoxycytidine - administration & dosage ; Deoxycytidine - analogs & derivatives ; Deoxycytidine - pharmacology ; Deoxycytidine - therapeutic use ; Drug Carriers - chemistry ; Drug Delivery Systems ; Drug Synergism ; efficacy ; Female ; gemcitabine ; Humans ; Lung - drug effects ; Lung - pathology ; Lung cancer ; Lung Neoplasms - drug therapy ; Lung Neoplasms - pathology ; Methods ; Mice, Inbred BALB C ; Mice, Nude ; micellar nanoparticles ; Micelles ; Neoplastic Stem Cells - drug effects ; Neoplastic Stem Cells - pathology ; phenformin ; Phenformin - administration & dosage ; Phenformin - pharmacology ; Phenformin - therapeutic use ; Physiological aspects ; Polycarboxylate Cement - chemistry ; Polyethylene Glycols - chemistry ; Stem cells ; Urea - analogs & derivatives]]></subject><ispartof>Nanomedicine (London, England), 2015-09, Vol.10 (18), p.2819-2832</ispartof><rights>Future Medicine Ltd</rights><rights>COPYRIGHT 2015 Future Medicine Ltd.</rights><rights>2015 Future Medicine Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-407b5cf5a35c4178d9ed88cbed416341d5c09a979c3722d67891e7db4563c6aa3</citedby><cites>FETCH-LOGICAL-c528t-407b5cf5a35c4178d9ed88cbed416341d5c09a979c3722d67891e7db4563c6aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26377155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krishnamurthy, Sangeetha</creatorcontrib><creatorcontrib>Ng, Victor WL</creatorcontrib><creatorcontrib>Gao, Shujun</creatorcontrib><creatorcontrib>Tan, Min-Han</creatorcontrib><creatorcontrib>Hedrick, James L</creatorcontrib><creatorcontrib>Yang, Yi Yan</creatorcontrib><title>Codelivery of dual drugs from polymeric micelles for simultaneous targeting of both cancer cells and cancer stem cells</title><title>Nanomedicine (London, England)</title><addtitle>Nanomedicine (Lond)</addtitle><description>Phenformin-loaded micelles (Phen M) were used in combination with gemcitabine-loaded micelles (Gem M) to study their combined effect against H460 human lung cancer cells and cancer stem cells (CSCs)
and
.
Gem M and Phen M were prepared via self-assembly of a mixture of a diblock copolymer of PEG and urea-functionalized polycarbonate (PEG-PUC) and a diblock copolymer of PEG and acid-functionalized polycarbonate (PEG-PAC) through hydrogen bonding and ionic interactions. Gem M and Phen M were characterized and tested for efficacy both
and
against cancer cells and CSCs.
The combination of Gem M/Phen M exhibited higher cytotoxicity against CSCs and non-CSCs than Gem M and Phen M alone, and showed significant cell cycle growth arrest
. The combination therapy had superior tumor suppression and apoptosis
without inducing toxicity to liver and kidney.
The combination of Gem M and Phen M may be potentially used in lung cancer therapy.</description><subject>Analysis</subject><subject>Animals</subject><subject>Antimetabolites, Antineoplastic - administration & dosage</subject><subject>Antimetabolites, Antineoplastic - pharmacology</subject><subject>Antimetabolites, Antineoplastic - therapeutic use</subject><subject>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</subject><subject>Antineoplastic Combined Chemotherapy Protocols - pharmacology</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>cancer stem cells</subject><subject>Care and treatment</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>codelivery</subject><subject>Deoxycytidine - administration & dosage</subject><subject>Deoxycytidine - analogs & derivatives</subject><subject>Deoxycytidine - pharmacology</subject><subject>Deoxycytidine - therapeutic use</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Delivery Systems</subject><subject>Drug Synergism</subject><subject>efficacy</subject><subject>Female</subject><subject>gemcitabine</subject><subject>Humans</subject><subject>Lung - drug effects</subject><subject>Lung - pathology</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Lung Neoplasms - pathology</subject><subject>Methods</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>micellar nanoparticles</subject><subject>Micelles</subject><subject>Neoplastic Stem Cells - drug effects</subject><subject>Neoplastic Stem Cells - pathology</subject><subject>phenformin</subject><subject>Phenformin - administration & dosage</subject><subject>Phenformin - pharmacology</subject><subject>Phenformin - therapeutic use</subject><subject>Physiological aspects</subject><subject>Polycarboxylate Cement - chemistry</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Stem cells</subject><subject>Urea - analogs & derivatives</subject><issn>1743-5889</issn><issn>1748-6963</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqFkk-L1TAUxYsozh_d-AEk4EaEPnubpEmWw0MdYcCNrkOa3D4ztMkzaQfetze1M4oyIFkkOfzOyU1yq-oVNLu2BfE-hGkHfAeNelKdg2Cy7lRHn_5a05pLqc6qi5xvm4bLFprn1VnbUSGA8_Pqbh8djv4O04nEgbjFjMSl5ZDJkOJEjnE8TZi8JZO3OI5Y9JhI9tMyziZgXDKZTTrg7MNhDejj_J1YEywmshoyMcE9CHnGaVNfVM8GM2Z8eT9fVt8-fvi6v65vvnz6vL-6qS1v5VyzRvTcDtxQbhkI6RQ6KW2PjkFHGThuG2WUUJaKtnWdkApQuJ7xjtrOGHpZvd1yjyn-WDDPevJ5rWCrXYNkHQOQEv6PCqCKlUNZQd_8g97GJYVykZVqBW8kyD_UwYyofRjinIxdQ_UVa6UUlAleqN0jVBkOy5PHgIMv-l-Gd5vBpphzwkEfk59MOmlo9NoPuvSDBl62qsCv7ytd-gndb_ShAQrQbcCwzEvCbD2Wr9Lbrji89QEfS_4JtYPCTA</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Krishnamurthy, Sangeetha</creator><creator>Ng, Victor WL</creator><creator>Gao, Shujun</creator><creator>Tan, Min-Han</creator><creator>Hedrick, James L</creator><creator>Yang, Yi Yan</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20150901</creationdate><title>Codelivery of dual drugs from polymeric micelles for simultaneous targeting of both cancer cells and cancer stem cells</title><author>Krishnamurthy, Sangeetha ; Ng, Victor WL ; Gao, Shujun ; Tan, Min-Han ; Hedrick, James L ; Yang, Yi Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-407b5cf5a35c4178d9ed88cbed416341d5c09a979c3722d67891e7db4563c6aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Analysis</topic><topic>Animals</topic><topic>Antimetabolites, Antineoplastic - 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pathology</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - drug therapy</topic><topic>Lung Neoplasms - pathology</topic><topic>Methods</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>micellar nanoparticles</topic><topic>Micelles</topic><topic>Neoplastic Stem Cells - drug effects</topic><topic>Neoplastic Stem Cells - pathology</topic><topic>phenformin</topic><topic>Phenformin - administration & dosage</topic><topic>Phenformin - pharmacology</topic><topic>Phenformin - therapeutic use</topic><topic>Physiological aspects</topic><topic>Polycarboxylate Cement - chemistry</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Stem cells</topic><topic>Urea - analogs & derivatives</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krishnamurthy, Sangeetha</creatorcontrib><creatorcontrib>Ng, Victor WL</creatorcontrib><creatorcontrib>Gao, Shujun</creatorcontrib><creatorcontrib>Tan, Min-Han</creatorcontrib><creatorcontrib>Hedrick, James L</creatorcontrib><creatorcontrib>Yang, Yi Yan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Nanomedicine (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krishnamurthy, Sangeetha</au><au>Ng, Victor WL</au><au>Gao, Shujun</au><au>Tan, Min-Han</au><au>Hedrick, James L</au><au>Yang, Yi Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Codelivery of dual drugs from polymeric micelles for simultaneous targeting of both cancer cells and cancer stem cells</atitle><jtitle>Nanomedicine (London, England)</jtitle><addtitle>Nanomedicine (Lond)</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>10</volume><issue>18</issue><spage>2819</spage><epage>2832</epage><pages>2819-2832</pages><issn>1743-5889</issn><eissn>1748-6963</eissn><abstract>Phenformin-loaded micelles (Phen M) were used in combination with gemcitabine-loaded micelles (Gem M) to study their combined effect against H460 human lung cancer cells and cancer stem cells (CSCs)
and
.
Gem M and Phen M were prepared via self-assembly of a mixture of a diblock copolymer of PEG and urea-functionalized polycarbonate (PEG-PUC) and a diblock copolymer of PEG and acid-functionalized polycarbonate (PEG-PAC) through hydrogen bonding and ionic interactions. Gem M and Phen M were characterized and tested for efficacy both
and
against cancer cells and CSCs.
The combination of Gem M/Phen M exhibited higher cytotoxicity against CSCs and non-CSCs than Gem M and Phen M alone, and showed significant cell cycle growth arrest
. The combination therapy had superior tumor suppression and apoptosis
without inducing toxicity to liver and kidney.
The combination of Gem M and Phen M may be potentially used in lung cancer therapy.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>26377155</pmid><doi>10.2217/nnm.15.109</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1743-5889 |
| ispartof | Nanomedicine (London, England), 2015-09, Vol.10 (18), p.2819-2832 |
| issn | 1743-5889 1748-6963 |
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| source | PubMed Central（OA） |
| subjects | Analysis Animals Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - pharmacology Antimetabolites, Antineoplastic - therapeutic use Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use cancer stem cells Care and treatment Cell Line, Tumor Cell Proliferation - drug effects codelivery Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Deoxycytidine - therapeutic use Drug Carriers - chemistry Drug Delivery Systems Drug Synergism efficacy Female gemcitabine Humans Lung - drug effects Lung - pathology Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - pathology Methods Mice, Inbred BALB C Mice, Nude micellar nanoparticles Micelles Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - pathology phenformin Phenformin - administration & dosage Phenformin - pharmacology Phenformin - therapeutic use Physiological aspects Polycarboxylate Cement - chemistry Polyethylene Glycols - chemistry Stem cells Urea - analogs & derivatives |
| title | Codelivery of dual drugs from polymeric micelles for simultaneous targeting of both cancer cells and cancer stem cells |
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