Roles of leptin and ghrelin in the regulation of the phenotype and cytokine production by NK cells from peripheral blood

Both leptin and ghrelin used separately at the concentrations corresponding to trimesters II–III of pregnancy increase the number of CD56 bright NK cells in mononuclear cell suspension; their combination also enhances the L-selectin expression on the surface of these cells in the culture. These horm...

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Bibliographic Details
Published in:Doklady. Biological sciences 2016-09, Vol.470 (1), p.249-252
Main Authors: Shirshev, S. V., Nekrasova, I. V., Orlova, E. G., Gorbunova, O. L.
Format: Article
Language:English
Subjects:
Adult
Biomedical and Life Sciences
Cell Biology
Cell Proliferation - physiology
Cells, Cultured
Cytokines - metabolism
Evolutionary Biology
Female
Gene Expression Regulation - immunology
Ghrelin - immunology
Humans
Killer Cells, Natural - cytology
Killer Cells, Natural - metabolism
Leptin - immunology
Leukocytes, Mononuclear - cytology
Leukocytes, Mononuclear - immunology
Life Sciences
Plant Sciences
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Summary:Both leptin and ghrelin used separately at the concentrations corresponding to trimesters II–III of pregnancy increase the number of CD56 bright NK cells in mononuclear cell suspension; their combination also enhances the L-selectin expression on the surface of these cells in the culture. These hormones do not affect the production of TGF-β1, IL-17А, or IFN-γ by NK cells, and they inhibit the production of IL-10. Leptin decreses the IL-4 production by NKp46 + cells, but the presence of ghrelin abrogates this effect.
ISSN:0012-4966
1608-3105
DOI:10.1134/S0012496616050136