Role of antibodies and IL17-mediated immunity in protection against pneumococcal otitis media

Highlights • Mucosal vaccination with PspA and CTB restricts pneumococcal colonization. • Vaccination reduces influenza-virus induced pneumococcal otitis media. • Protection was correlated with a balanced anti-PspA IgG1:IgG2a ratio. • Vaccination induces a mucosal Th17 response against PspA. • Mice...

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Bibliographic Details
Published in:Vaccine 2016-11, Vol.34 (48), p.5968-5974
Main Authors: Habets, Marrit N, van Selm, Saskia, van Opzeeland, Fred J, Simonetti, Elles, Hermans, Peter W.M, de Jonge, Marien I, Diavatopoulos, Dimitri A
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Administration, Intranasal
Allergy and Immunology
Animals
Antibodies, Bacterial - blood
Antibodies, Bacterial - immunology
Antibody
Antigens
Bacterial Load
Bacterial Proteins - immunology
Colonization
Disease Models, Animal
Ear diseases
Ear, Middle - microbiology
Ears & hearing
Experiments
Immunity, Mucosal
Immunoglobulin A - immunology
Immunoglobulins
Influenza
Interleukin-17
Interleukin-17 - deficiency
Interleukin-17 - immunology
Laboratories
Medical research
Mice, Inbred BALB C
Mucosal vaccination
Otitis media
Otitis Media - immunology
Otitis Media - prevention & control
Otitis Media - virology
Pneumococcal Infections - immunology
Pneumococcal Infections - microbiology
Pneumococcal Infections - prevention & control
Pneumococcal surface protein A
Pneumococcal Vaccines - administration & dosage
Pneumococcal Vaccines - immunology
Rodents
Streptococcus infections
Streptococcus pneumoniae
Streptococcus pneumoniae - immunology
Streptococcus pneumoniae - isolation & purification
Th17 Cells - immunology
Vaccination - methods
Vaccines
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Summary:Highlights • Mucosal vaccination with PspA and CTB restricts pneumococcal colonization. • Vaccination reduces influenza-virus induced pneumococcal otitis media. • Protection was correlated with a balanced anti-PspA IgG1:IgG2a ratio. • Vaccination induces a mucosal Th17 response against PspA. • Mice deficient in IL-17 signaling were not protected by vaccination.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2016.09.057