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Lipid and inflammatory biomarker profiles in early insulin resistance
Aims To analyze the serum lipid and inflammatory biomarker profile in the early insulin resistance (e-IR). Methods Cross-sectional study of 5943 adults without diabetes, stratified into no IR group (C-peptide
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| Published in: | Acta diabetologica 2016-12, Vol.53 (6), p.905-913 |
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| container_end_page | 913 |
| container_issue | 6 |
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| container_title | Acta diabetologica |
| container_volume | 53 |
| creator | Marcelino Rodríguez, Itahisa Oliva García, José Alemán Sánchez, José Juan Almeida González, Delia Domínguez Coello, Santiago Brito Díaz, Buenaventura Gannar, Fadoua Rodríguez Pérez, María del Cristo Elosua, Roberto Cabrera de León, Antonio |
| description | Aims
To analyze the serum lipid and inflammatory biomarker profile in the early insulin resistance (e-IR).
Methods
Cross-sectional study of 5943 adults without diabetes, stratified into no IR group (C-peptide |
| doi_str_mv | 10.1007/s00592-016-0885-6 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1846416542</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4253438301</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-3c77f7bfe9511efd80de182362ab581b337f2c35f7abe58d318d3f0f41eb2eb33</originalsourceid><addsrcrecordid>eNqNkUtLxDAUhYMozjj6A9xIwY2baF5N0qUM4wMG3Og6pO2NZOxjTKaL-femVEUEwUVIwvlybu49CJ1Tck0JUTeRkLxgmFCJidY5lgdoTgVnOGecH6I5KQTBuWDFDJ3EuCGEMsX1MZoxlSgh-Byt1n7r68x2deY719i2tbs-7LPS960NbxCybeidbyAmPQMbmn06xKFJtwDRx53tKjhFR842Ec4-9wV6uVs9Lx_w-un-cXm7xpUQeod5pZRTpYMipxRcrUkNVDMumS1zTUvOlWMVz52yJeS65jQtR5ygUDJI8gJdTb7pU-8DxJ1pfaygaWwH_RAN1UIKKlPL_0CZVExLJRN6-Qvd9EPoUiOjISlUmilJFJ2oKvQxBnBmG3ya0d5QYsY4zBSHSXGYMQ4zOl98Og9lC_X3i6_5J4BNQExS9wrhR-k_XT8AX5CUZA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1840971430</pqid></control><display><type>article</type><title>Lipid and inflammatory biomarker profiles in early insulin resistance</title><source>Springer Nature</source><creator>Marcelino Rodríguez, Itahisa ; Oliva García, José ; Alemán Sánchez, José Juan ; Almeida González, Delia ; Domínguez Coello, Santiago ; Brito Díaz, Buenaventura ; Gannar, Fadoua ; Rodríguez Pérez, María del Cristo ; Elosua, Roberto ; Cabrera de León, Antonio</creator><creatorcontrib>Marcelino Rodríguez, Itahisa ; Oliva García, José ; Alemán Sánchez, José Juan ; Almeida González, Delia ; Domínguez Coello, Santiago ; Brito Díaz, Buenaventura ; Gannar, Fadoua ; Rodríguez Pérez, María del Cristo ; Elosua, Roberto ; Cabrera de León, Antonio</creatorcontrib><description><![CDATA[Aims
To analyze the serum lipid and inflammatory biomarker profile in the early insulin resistance (e-IR).
Methods
Cross-sectional study of 5943 adults without diabetes, stratified into no IR group (C-peptide <third tertile and glucose <100 mg/dL), e-IR group (C-peptide ≥third tertile and glucose <100 mg/dL) and advanced IR group (glucose ≥100 mg/dL).
Results
E-IR showed significant differences with no IR in the serum concentration of triglycerides (
P
< 0.001), HDL cholesterol (
P
< 0.001), LDL cholesterol (
P
< 0.001), sCD40L (
P
< 0.001), C-reactive protein (
P
< 0.004), leptin (
P
< 0.001) and adiponectin (
P
< 0.001). Adjusting for age, gender and abdominal obesity, corroborated the association of e-IR with highest quintile of triglycerides (OR 3.88 [3.07–4.89]), HDL cholesterol (OR 0.35 [0.28–0.44]), sCD40L (OR 0.47 [0.24–0.94]), C-reactive protein (OR 2.31 [1.29–4.12]), adiponectin (OR 0.11 [0.04–0.32]), PAI-1 (OR 3.29 [1.29–8.40]) and resistin (OR 1.25 [1.01–1.54]); the same biomarkers were associated with advanced IR although resistin was a protective factor (OR 0.73 [0.58–0.93]).
Conclusions
Euglycemic patients with e-IR present an unfavorable serum lipid and inflammatory biomarker profile. Measuring C-peptide in euglycemic patients with elevated triglycerides identifies e-IR.]]></description><identifier>ISSN: 0940-5429</identifier><identifier>EISSN: 1432-5233</identifier><identifier>DOI: 10.1007/s00592-016-0885-6</identifier><identifier>PMID: 27432443</identifier><identifier>CODEN: ACDAEZ</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Adipokines - blood ; Adult ; Age of Onset ; Aged ; Biomarkers ; Biomarkers - blood ; Blood Glucose - analysis ; C-Peptide - blood ; C-Reactive Protein - metabolism ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Cross-Sectional Studies ; Diabetes ; Female ; Humans ; Inflammatory diseases ; Insulin resistance ; Internal Medicine ; Lipids ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolic Syndrome - blood ; Metabolic Syndrome - epidemiology ; Middle Aged ; Original Article ; Plasminogen Activator Inhibitor 1 - blood ; Protective Factors ; Risk Factors ; Spain - epidemiology ; Triglycerides - blood</subject><ispartof>Acta diabetologica, 2016-12, Vol.53 (6), p.905-913</ispartof><rights>Springer-Verlag Italia 2016</rights><rights>Acta Diabetologica is a copyright of Springer, 2016.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-3c77f7bfe9511efd80de182362ab581b337f2c35f7abe58d318d3f0f41eb2eb33</citedby><cites>FETCH-LOGICAL-c448t-3c77f7bfe9511efd80de182362ab581b337f2c35f7abe58d318d3f0f41eb2eb33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27432443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marcelino Rodríguez, Itahisa</creatorcontrib><creatorcontrib>Oliva García, José</creatorcontrib><creatorcontrib>Alemán Sánchez, José Juan</creatorcontrib><creatorcontrib>Almeida González, Delia</creatorcontrib><creatorcontrib>Domínguez Coello, Santiago</creatorcontrib><creatorcontrib>Brito Díaz, Buenaventura</creatorcontrib><creatorcontrib>Gannar, Fadoua</creatorcontrib><creatorcontrib>Rodríguez Pérez, María del Cristo</creatorcontrib><creatorcontrib>Elosua, Roberto</creatorcontrib><creatorcontrib>Cabrera de León, Antonio</creatorcontrib><title>Lipid and inflammatory biomarker profiles in early insulin resistance</title><title>Acta diabetologica</title><addtitle>Acta Diabetol</addtitle><addtitle>Acta Diabetol</addtitle><description><![CDATA[Aims
To analyze the serum lipid and inflammatory biomarker profile in the early insulin resistance (e-IR).
Methods
Cross-sectional study of 5943 adults without diabetes, stratified into no IR group (C-peptide <third tertile and glucose <100 mg/dL), e-IR group (C-peptide ≥third tertile and glucose <100 mg/dL) and advanced IR group (glucose ≥100 mg/dL).
Results
E-IR showed significant differences with no IR in the serum concentration of triglycerides (
P
< 0.001), HDL cholesterol (
P
< 0.001), LDL cholesterol (
P
< 0.001), sCD40L (
P
< 0.001), C-reactive protein (
P
< 0.004), leptin (
P
< 0.001) and adiponectin (
P
< 0.001). Adjusting for age, gender and abdominal obesity, corroborated the association of e-IR with highest quintile of triglycerides (OR 3.88 [3.07–4.89]), HDL cholesterol (OR 0.35 [0.28–0.44]), sCD40L (OR 0.47 [0.24–0.94]), C-reactive protein (OR 2.31 [1.29–4.12]), adiponectin (OR 0.11 [0.04–0.32]), PAI-1 (OR 3.29 [1.29–8.40]) and resistin (OR 1.25 [1.01–1.54]); the same biomarkers were associated with advanced IR although resistin was a protective factor (OR 0.73 [0.58–0.93]).
Conclusions
Euglycemic patients with e-IR present an unfavorable serum lipid and inflammatory biomarker profile. Measuring C-peptide in euglycemic patients with elevated triglycerides identifies e-IR.]]></description><subject>Adipokines - blood</subject><subject>Adult</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood Glucose - analysis</subject><subject>C-Peptide - blood</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammatory diseases</subject><subject>Insulin resistance</subject><subject>Internal Medicine</subject><subject>Lipids</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Plasminogen Activator Inhibitor 1 - blood</subject><subject>Protective Factors</subject><subject>Risk Factors</subject><subject>Spain - epidemiology</subject><subject>Triglycerides - blood</subject><issn>0940-5429</issn><issn>1432-5233</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkUtLxDAUhYMozjj6A9xIwY2baF5N0qUM4wMG3Og6pO2NZOxjTKaL-femVEUEwUVIwvlybu49CJ1Tck0JUTeRkLxgmFCJidY5lgdoTgVnOGecH6I5KQTBuWDFDJ3EuCGEMsX1MZoxlSgh-Byt1n7r68x2deY719i2tbs-7LPS960NbxCybeidbyAmPQMbmn06xKFJtwDRx53tKjhFR842Ec4-9wV6uVs9Lx_w-un-cXm7xpUQeod5pZRTpYMipxRcrUkNVDMumS1zTUvOlWMVz52yJeS65jQtR5ygUDJI8gJdTb7pU-8DxJ1pfaygaWwH_RAN1UIKKlPL_0CZVExLJRN6-Qvd9EPoUiOjISlUmilJFJ2oKvQxBnBmG3ya0d5QYsY4zBSHSXGYMQ4zOl98Og9lC_X3i6_5J4BNQExS9wrhR-k_XT8AX5CUZA</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Marcelino Rodríguez, Itahisa</creator><creator>Oliva García, José</creator><creator>Alemán Sánchez, José Juan</creator><creator>Almeida González, Delia</creator><creator>Domínguez Coello, Santiago</creator><creator>Brito Díaz, Buenaventura</creator><creator>Gannar, Fadoua</creator><creator>Rodríguez Pérez, María del Cristo</creator><creator>Elosua, Roberto</creator><creator>Cabrera de León, Antonio</creator><general>Springer Milan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20161201</creationdate><title>Lipid and inflammatory biomarker profiles in early insulin resistance</title><author>Marcelino Rodríguez, Itahisa ; Oliva García, José ; Alemán Sánchez, José Juan ; Almeida González, Delia ; Domínguez Coello, Santiago ; Brito Díaz, Buenaventura ; Gannar, Fadoua ; Rodríguez Pérez, María del Cristo ; Elosua, Roberto ; Cabrera de León, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-3c77f7bfe9511efd80de182362ab581b337f2c35f7abe58d318d3f0f41eb2eb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adipokines - blood</topic><topic>Adult</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Blood Glucose - analysis</topic><topic>C-Peptide - blood</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammatory diseases</topic><topic>Insulin resistance</topic><topic>Internal Medicine</topic><topic>Lipids</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Plasminogen Activator Inhibitor 1 - blood</topic><topic>Protective Factors</topic><topic>Risk Factors</topic><topic>Spain - epidemiology</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marcelino Rodríguez, Itahisa</creatorcontrib><creatorcontrib>Oliva García, José</creatorcontrib><creatorcontrib>Alemán Sánchez, José Juan</creatorcontrib><creatorcontrib>Almeida González, Delia</creatorcontrib><creatorcontrib>Domínguez Coello, Santiago</creatorcontrib><creatorcontrib>Brito Díaz, Buenaventura</creatorcontrib><creatorcontrib>Gannar, Fadoua</creatorcontrib><creatorcontrib>Rodríguez Pérez, María del Cristo</creatorcontrib><creatorcontrib>Elosua, Roberto</creatorcontrib><creatorcontrib>Cabrera de León, Antonio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest_Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Acta diabetologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marcelino Rodríguez, Itahisa</au><au>Oliva García, José</au><au>Alemán Sánchez, José Juan</au><au>Almeida González, Delia</au><au>Domínguez Coello, Santiago</au><au>Brito Díaz, Buenaventura</au><au>Gannar, Fadoua</au><au>Rodríguez Pérez, María del Cristo</au><au>Elosua, Roberto</au><au>Cabrera de León, Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipid and inflammatory biomarker profiles in early insulin resistance</atitle><jtitle>Acta diabetologica</jtitle><stitle>Acta Diabetol</stitle><addtitle>Acta Diabetol</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>53</volume><issue>6</issue><spage>905</spage><epage>913</epage><pages>905-913</pages><issn>0940-5429</issn><eissn>1432-5233</eissn><coden>ACDAEZ</coden><abstract><![CDATA[Aims
To analyze the serum lipid and inflammatory biomarker profile in the early insulin resistance (e-IR).
Methods
Cross-sectional study of 5943 adults without diabetes, stratified into no IR group (C-peptide <third tertile and glucose <100 mg/dL), e-IR group (C-peptide ≥third tertile and glucose <100 mg/dL) and advanced IR group (glucose ≥100 mg/dL).
Results
E-IR showed significant differences with no IR in the serum concentration of triglycerides (
P
< 0.001), HDL cholesterol (
P
< 0.001), LDL cholesterol (
P
< 0.001), sCD40L (
P
< 0.001), C-reactive protein (
P
< 0.004), leptin (
P
< 0.001) and adiponectin (
P
< 0.001). Adjusting for age, gender and abdominal obesity, corroborated the association of e-IR with highest quintile of triglycerides (OR 3.88 [3.07–4.89]), HDL cholesterol (OR 0.35 [0.28–0.44]), sCD40L (OR 0.47 [0.24–0.94]), C-reactive protein (OR 2.31 [1.29–4.12]), adiponectin (OR 0.11 [0.04–0.32]), PAI-1 (OR 3.29 [1.29–8.40]) and resistin (OR 1.25 [1.01–1.54]); the same biomarkers were associated with advanced IR although resistin was a protective factor (OR 0.73 [0.58–0.93]).
Conclusions
Euglycemic patients with e-IR present an unfavorable serum lipid and inflammatory biomarker profile. Measuring C-peptide in euglycemic patients with elevated triglycerides identifies e-IR.]]></abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>27432443</pmid><doi>10.1007/s00592-016-0885-6</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0940-5429 |
| ispartof | Acta diabetologica, 2016-12, Vol.53 (6), p.905-913 |
| issn | 0940-5429 1432-5233 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1846416542 |
| source | Springer Nature |
| subjects | Adipokines - blood Adult Age of Onset Aged Biomarkers Biomarkers - blood Blood Glucose - analysis C-Peptide - blood C-Reactive Protein - metabolism Cholesterol, HDL - blood Cholesterol, LDL - blood Cross-Sectional Studies Diabetes Female Humans Inflammatory diseases Insulin resistance Internal Medicine Lipids Male Medicine Medicine & Public Health Metabolic Diseases Metabolic Syndrome - blood Metabolic Syndrome - epidemiology Middle Aged Original Article Plasminogen Activator Inhibitor 1 - blood Protective Factors Risk Factors Spain - epidemiology Triglycerides - blood |
| title | Lipid and inflammatory biomarker profiles in early insulin resistance |
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