Cover Picture: Development of Potent and Metabolically Stable APJ Ligands with High Therapeutic Potential (ChemMedChem 21/2016)

The front cover picture shows the stabilized apelin‐13 peptide illustrated by a knight sitting on a horse, protected by lance and shield. The shortest known endogenous apelin receptor ligand was modified by unnatural amino acids, cyclization, and palmitoylation to increase the metabolic stability. I...

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Bibliographic Details
Published in:ChemMedChem 2016-11, Vol.11 (21), p.2362-2362
Main Authors: Juhl, Cathleen, Els-Heindl, Sylvia, Schönauer, Ria, Redlich, Gorden, Haaf, Erik, Wunder, Frank, Riedl, Bernd, Burkhardt, Nils, Beck-Sickinger, Annette G., Bierer, Donald
Format: Article
Language:English
Subjects:
apelin
G protein-coupled receptors
lipidation
peptides
structure-activity relationships
Online Access:Get full text
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Summary:The front cover picture shows the stabilized apelin‐13 peptide illustrated by a knight sitting on a horse, protected by lance and shield. The shortest known endogenous apelin receptor ligand was modified by unnatural amino acids, cyclization, and palmitoylation to increase the metabolic stability. In vitro and in vivo stability tests revealed a very active and stable apelin analog, which will be beneficial to facilitate in vivo investigation of apelin effects and progress drug development. More information can be found in the Full Paper by Donald Bierer et al. on page 2378 in Issue 21, 2016 (DOI: 10.1002/cmdc.201600307). Artwork by Stefanie Wittrisch.
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.201600531