Salbutamol effects on systemic potassium dynamics during and following intense continuous and intermittent exercise

Purpose Salbutamol inhalation is permissible by WADA in athletic competition for asthma management and affects potassium regulation, which is vital for muscle function. Salbutamol effects on arterial potassium concentration ([K + ] a ) during and after high-intensity continuous exercise (HI cont ) a...

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Bibliographic Details
Published in:European journal of applied physiology 2016-12, Vol.116 (11-12), p.2389-2399
Main Authors: Altarawneh, Muath M., Petersen, Aaron, Smith, Robert, Rouffet, David M., Billaut, Francois, Perry, Ben D., Wyckelsma, Victoria L., Tobin, Antony, McKenna, Michael J.
Format: Article
Language:English
Subjects:
Administration, Inhalation
Albuterol - administration & dosage
Asthma
Biomedical and Life Sciences
Biomedicine
Bronchodilator Agents - administration & dosage
Cross-Over Studies
Dose-Response Relationship, Drug
Double-Blind Method
Drugs & sports
Exercise - physiology
High-Intensity Interval Training - methods
Human Physiology
Humans
Male
Metabolic Clearance Rate - drug effects
Musculoskeletal system
Occupational Medicine/Industrial Medicine
Original Article
Physical Endurance - drug effects
Physical Endurance - physiology
Physical Exertion - drug effects
Physical Exertion - physiology
Plasma
Potassium
Potassium - blood
Sports Medicine
Treatment Outcome
Young Adult
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Summary:Purpose Salbutamol inhalation is permissible by WADA in athletic competition for asthma management and affects potassium regulation, which is vital for muscle function. Salbutamol effects on arterial potassium concentration ([K + ] a ) during and after high-intensity continuous exercise (HI cont ) and intermittent exercise comprising repeated, brief sprints (HI int ), and on performance during HI int are unknown and were investigated. Methods Seven recreationally active men participated in a double-blind, randomised, cross-over design, inhaling 1000 µg salbutamol or placebo. Participants cycled continuously for 5 min at 40 % V ˙ O 2peak and 60 % V ˙ O 2peak , then HI cont (90 s at 130 % V ˙ O 2peak ), 20 min recovery, and then HI int (3 sets, 5 × 4 s sprints), with 30 min recovery. Results Plasma [K + ] a increased throughout exercise and subsequently declined below baseline ( P  
ISSN:1439-6319
1439-6327
DOI:10.1007/s00421-016-3481-0