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The significance and predictive value of free light chains in the urine of patients with chronic inflammatory rheumatic disease
In patients with rheumatic diseases, reliable markers for determining disease activity are scarce. One potential parameter is the level of immunoglobulin free light chains (FLCs), which is known to be elevated in the blood of patients with certain rheumatic diseases. Few studies have quantified FLCs...
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| Published in: | Clinical rheumatology 2016-12, Vol.35 (12), p.2939-2946 |
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| container_end_page | 2946 |
| container_issue | 12 |
| container_start_page | 2939 |
| container_title | Clinical rheumatology |
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| creator | Bramlage, Carsten Paul Froelich, Britta Wallbach, Manuel Minguet, Joan Grupp, Clemens Deutsch, Cornelia Bramlage, Peter Koziolek, Michael Müller, Gerhard Anton |
| description | In patients with rheumatic diseases, reliable markers for determining disease activity are scarce. One potential parameter is the level of immunoglobulin free light chains (FLCs), which is known to be elevated in the blood of patients with certain rheumatic diseases. Few studies have quantified FLCs in urine, a convenient source of test sample, in patients with different rheumatic diseases. We carried out a retrospective analysis of patients with rheumatic disease attending the University hospital of Goettingen, Germany. Subjects were included if they had urine levels of both
κ
and
λ
FLCs available and did not have myeloma. Data regarding systemic inflammation and kidney function were recorded, and FLC levels were correlated with inflammatory markers. Of the 382 patients with rheumatic disease, 40.1 % had chronic polyarthritis, 21.2 % connective tissue disease, 18.6 % spondyloarthritis and 15.7 % vasculitis. Elevated levels of
κ
FLCs were found for 84 % of patients and elevated
λ
for 52.7 %. For the patients with rheumatoid arthritis, FLCs correlated with C-reactive protein (
κ
,
r
= 0.368,
p
|
| doi_str_mv | 10.1007/s10067-016-3437-0 |
| format | article |
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κ
and
λ
FLCs available and did not have myeloma. Data regarding systemic inflammation and kidney function were recorded, and FLC levels were correlated with inflammatory markers. Of the 382 patients with rheumatic disease, 40.1 % had chronic polyarthritis, 21.2 % connective tissue disease, 18.6 % spondyloarthritis and 15.7 % vasculitis. Elevated levels of
κ
FLCs were found for 84 % of patients and elevated
λ
for 52.7 %. For the patients with rheumatoid arthritis, FLCs correlated with C-reactive protein (
κ
,
r
= 0.368,
p
< 0.001;
λ
,
r
= 0.398,
p
< 0.001) and erythrocyte sedimentation rate (
κ
,
r
= 0.692,
p
< 0.001;
λ
,
r
= 0.612,
p
< 0.001). Patients being treated with rituximab displayed FLC levels similar to those of the reference group. There were clear elevations in both
κ
and
λ
FLCs in patients with rheumatic disease, but not in
κ
/
λ
ratio. The correlation between FLCs and inflammatory markers in patients with rheumatoid arthritis demonstrates their potential for predicting disease activity.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-016-3437-0</identifier><identifier>PMID: 27734231</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Adult ; Aged ; Blood Sedimentation ; C-Reactive Protein - metabolism ; Female ; Humans ; Immunoglobulin kappa-Chains - chemistry ; Immunoglobulin kappa-Chains - urine ; Immunoglobulin lambda-Chains - chemistry ; Immunoglobulin lambda-Chains - urine ; Inflammation - diagnosis ; Inflammation - immunology ; Inflammation - urine ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Predictive Value of Tests ; Retrospective Studies ; Rheumatic Diseases - diagnosis ; Rheumatic Diseases - immunology ; Rheumatic Diseases - urine ; Rheumatology ; Rituximab - administration & dosage</subject><ispartof>Clinical rheumatology, 2016-12, Vol.35 (12), p.2939-2946</ispartof><rights>International League of Associations for Rheumatology (ILAR) 2016</rights><rights>Clinical Rheumatology is a copyright of Springer, 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-dd16aeeff239ca15ed207b0dbcbbfc56568c77bfb861d3c48821ed5530a8bfbe3</citedby><cites>FETCH-LOGICAL-c405t-dd16aeeff239ca15ed207b0dbcbbfc56568c77bfb861d3c48821ed5530a8bfbe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27734231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bramlage, Carsten Paul</creatorcontrib><creatorcontrib>Froelich, Britta</creatorcontrib><creatorcontrib>Wallbach, Manuel</creatorcontrib><creatorcontrib>Minguet, Joan</creatorcontrib><creatorcontrib>Grupp, Clemens</creatorcontrib><creatorcontrib>Deutsch, Cornelia</creatorcontrib><creatorcontrib>Bramlage, Peter</creatorcontrib><creatorcontrib>Koziolek, Michael</creatorcontrib><creatorcontrib>Müller, Gerhard Anton</creatorcontrib><title>The significance and predictive value of free light chains in the urine of patients with chronic inflammatory rheumatic disease</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>In patients with rheumatic diseases, reliable markers for determining disease activity are scarce. One potential parameter is the level of immunoglobulin free light chains (FLCs), which is known to be elevated in the blood of patients with certain rheumatic diseases. Few studies have quantified FLCs in urine, a convenient source of test sample, in patients with different rheumatic diseases. We carried out a retrospective analysis of patients with rheumatic disease attending the University hospital of Goettingen, Germany. Subjects were included if they had urine levels of both
κ
and
λ
FLCs available and did not have myeloma. Data regarding systemic inflammation and kidney function were recorded, and FLC levels were correlated with inflammatory markers. Of the 382 patients with rheumatic disease, 40.1 % had chronic polyarthritis, 21.2 % connective tissue disease, 18.6 % spondyloarthritis and 15.7 % vasculitis. Elevated levels of
κ
FLCs were found for 84 % of patients and elevated
λ
for 52.7 %. For the patients with rheumatoid arthritis, FLCs correlated with C-reactive protein (
κ
,
r
= 0.368,
p
< 0.001;
λ
,
r
= 0.398,
p
< 0.001) and erythrocyte sedimentation rate (
κ
,
r
= 0.692,
p
< 0.001;
λ
,
r
= 0.612,
p
< 0.001). Patients being treated with rituximab displayed FLC levels similar to those of the reference group. There were clear elevations in both
κ
and
λ
FLCs in patients with rheumatic disease, but not in
κ
/
λ
ratio. The correlation between FLCs and inflammatory markers in patients with rheumatoid arthritis demonstrates their potential for predicting disease activity.</description><subject>Adult</subject><subject>Aged</subject><subject>Blood Sedimentation</subject><subject>C-Reactive Protein - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin kappa-Chains - chemistry</subject><subject>Immunoglobulin kappa-Chains - urine</subject><subject>Immunoglobulin lambda-Chains - chemistry</subject><subject>Immunoglobulin lambda-Chains - urine</subject><subject>Inflammation - diagnosis</subject><subject>Inflammation - immunology</subject><subject>Inflammation - urine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Predictive Value of Tests</subject><subject>Retrospective Studies</subject><subject>Rheumatic Diseases - diagnosis</subject><subject>Rheumatic Diseases - immunology</subject><subject>Rheumatic Diseases - urine</subject><subject>Rheumatology</subject><subject>Rituximab - administration & dosage</subject><issn>0770-3198</issn><issn>1434-9949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkU9rFTEUxUNR2tfaD9CNBNy4Gc2_mWSWpagVCm7qOmSSmzcpM5nXJFPpyq9unq8tIghuksu9v3NC7kHogpIPlBD5Mdezkw2hXcMFr8UR2lDBRdP3on-FNkRK0nDaqxN0mvMdIYSpnh6jEyYlF4zTDfp5OwLOYRuDD9ZEC9hEh3cJXLAlPAB-MNMKePHYJwA8he1YsB1NiBmHiEtVrynE38TOlACxZPwjlLFCaYnBVspPZp5NWdIjTiOstaxtFzKYDG_Qa2-mDOdP9xn6_vnT7dV1c_Pty9ery5vGCtKWxjnaGQDvGe-toS04RuRA3GCHwdu2aztlpRz8oDrquBVKMQqubTkxqnaBn6H3B99dWu5XyEXPIVuYJhNhWbOmSnR1I5Lx_0B5K6jopajou7_Qu2VNsX5kb0j7TqqWVYoeKJuWnBN4vUthNulRU6L3QepDkLoGqfdBalI1b5-c12EG96J4Tq4C7ADkOopbSH88_U_XX1-Fqo8</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Bramlage, Carsten Paul</creator><creator>Froelich, Britta</creator><creator>Wallbach, Manuel</creator><creator>Minguet, Joan</creator><creator>Grupp, Clemens</creator><creator>Deutsch, Cornelia</creator><creator>Bramlage, Peter</creator><creator>Koziolek, Michael</creator><creator>Müller, Gerhard Anton</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20161201</creationdate><title>The significance and predictive value of free light chains in the urine of patients with chronic inflammatory rheumatic disease</title><author>Bramlage, Carsten Paul ; 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One potential parameter is the level of immunoglobulin free light chains (FLCs), which is known to be elevated in the blood of patients with certain rheumatic diseases. Few studies have quantified FLCs in urine, a convenient source of test sample, in patients with different rheumatic diseases. We carried out a retrospective analysis of patients with rheumatic disease attending the University hospital of Goettingen, Germany. Subjects were included if they had urine levels of both
κ
and
λ
FLCs available and did not have myeloma. Data regarding systemic inflammation and kidney function were recorded, and FLC levels were correlated with inflammatory markers. Of the 382 patients with rheumatic disease, 40.1 % had chronic polyarthritis, 21.2 % connective tissue disease, 18.6 % spondyloarthritis and 15.7 % vasculitis. Elevated levels of
κ
FLCs were found for 84 % of patients and elevated
λ
for 52.7 %. For the patients with rheumatoid arthritis, FLCs correlated with C-reactive protein (
κ
,
r
= 0.368,
p
< 0.001;
λ
,
r
= 0.398,
p
< 0.001) and erythrocyte sedimentation rate (
κ
,
r
= 0.692,
p
< 0.001;
λ
,
r
= 0.612,
p
< 0.001). Patients being treated with rituximab displayed FLC levels similar to those of the reference group. There were clear elevations in both
κ
and
λ
FLCs in patients with rheumatic disease, but not in
κ
/
λ
ratio. The correlation between FLCs and inflammatory markers in patients with rheumatoid arthritis demonstrates their potential for predicting disease activity.</abstract><cop>London</cop><pub>Springer London</pub><pmid>27734231</pmid><doi>10.1007/s10067-016-3437-0</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0770-3198 |
| ispartof | Clinical rheumatology, 2016-12, Vol.35 (12), p.2939-2946 |
| issn | 0770-3198 1434-9949 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1846423723 |
| source | Springer Nature |
| subjects | Adult Aged Blood Sedimentation C-Reactive Protein - metabolism Female Humans Immunoglobulin kappa-Chains - chemistry Immunoglobulin kappa-Chains - urine Immunoglobulin lambda-Chains - chemistry Immunoglobulin lambda-Chains - urine Inflammation - diagnosis Inflammation - immunology Inflammation - urine Male Medicine Medicine & Public Health Middle Aged Original Article Predictive Value of Tests Retrospective Studies Rheumatic Diseases - diagnosis Rheumatic Diseases - immunology Rheumatic Diseases - urine Rheumatology Rituximab - administration & dosage |
| title | The significance and predictive value of free light chains in the urine of patients with chronic inflammatory rheumatic disease |
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